methyl 4-{5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}phenyl ether

Base Information

• Chemical Name: methyl 4-{5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}phenyl ether
• CAS No.: 724432-26-2
• Molecular Formula: C₁₆H₁₁F₃N₂O₂
• Molecular Weight: 320.271
• Mol file: 724432-26-2.mol

Synonyms:2-(4-methoxyphenyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Chemical Property of methyl 4-{5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}phenyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-{5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}phenyl ether

There total 3 articles about methyl 4-{5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}phenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

5-(4’-trifluoromethylphenyl)-1H-tetrazole (2251-79-8) + 4-methoxybenzoic acid (100-09-4) → 2-(4-methoxyphenyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (724432-26-2)

Guidance literature:

With diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 1h; UV-irradiation; Flow reactor;

DOI:10.1002/chem.202002896

Reference yield:

methyl 4-(trifluoromethyl)benzoate (2967-66-0) → 2-(4-methoxyphenyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (724432-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine

2: pyridine / Heating

3: trichlorophosphate / 10 h / Reflux

With pyridine; hydrazine; trichlorophosphate;

DOI:10.1002/mrc.2804

Reference yield:

C16H13F3N2O3 (790681-33-3) → 2-(4-methoxyphenyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (724432-26-2)

Guidance literature:

With trichlorophosphate; for 10h; Reflux;

DOI:10.1002/mrc.2804

upstream raw materials:

C₁₆H₁₃F₃N₂O₃

methyl 4-(trifluoromethyl)benzoate

5-(4’-trifluoromethylphenyl)-1H-tetrazole

4-methoxybenzoic acid