6-fluoro-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol

Base Information

Chemical Name:6-fluoro-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol
CAS No.:1437779-64-0
Molecular Formula:C₁₉H₁₃BCl₃F₄NO₃
Molecular Weight:496.481
Hs Code.:

Synonyms:6-fluoro-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol

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Chemical Property of 6-fluoro-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol

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Technology Process of 6-fluoro-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol

There total 12 articles about 6-fluoro-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864736-87-8
1,2,3-trichloro-5-(1,1,1-trifluoroprop-2-en-2-yl)benzene

: 1437780-20-5
6-fluoro-N,1-dihydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborole-5-carbimidoyl chloride

: 1437779-64-0
6-fluoro-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 403-15-6
4-fluoro-3-methyl-benzoic acid

: 1437779-64-0
6-fluoro-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol

Guidance literature:: Multi-step reaction with 12 steps

1.1: potassium nitrite; sulfuric acid / 2 h / 20 °C

2.1: thionyl chloride / Reflux

3.1: hydrogen; palladium 10% on activated carbon / 760.05 Torr

4.1: sodium nitrite; hydrogen bromide / water / 0.5 h / 0 °C

4.2: 1 h / 0 - 20 °C

5.1: methyl magnesium iodide / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

7.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C / Inert atmosphere

8.1: hydrogenchloride / tetrahydrofuran; water / 20 °C

9.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 16 h / Reflux

10.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; water / 2 h / 20 °C

11.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 45 °C

12.1: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; N-Bromosuccinimide; methyl magnesium iodide; thionyl chloride; potassium nitrite; sulfuric acid; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen bromide; hydrogen; potassium acetate; sodium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium nitrite; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1037206-86-2
methyl 2-amino-4-fluoro-5-methylbenzoate

: 1437779-64-0
6-fluoro-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium nitrite; hydrogen bromide / water / 0.5 h / 0 °C

1.2: 1 h / 0 - 20 °C

2.1: methyl magnesium iodide / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C / Inert atmosphere

5.1: hydrogenchloride / tetrahydrofuran; water / 20 °C

6.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 16 h / Reflux

7.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; water / 2 h / 20 °C

8.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 45 °C

9.1: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; N-Bromosuccinimide; methyl magnesium iodide; hydroxylamine hydrochloride; hydrogen bromide; potassium acetate; sodium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium nitrite; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; water; N,N-dimethyl-formamide;