1,3-Bis-(4-tert-butyl-phenyl)-5,6-dimethyl-benzo[c]thiophene

Base Information

• Chemical Name: 1,3-Bis-(4-tert-butyl-phenyl)-5,6-dimethyl-benzo[c]thiophene
• CAS No.: 130443-18-4
• Molecular Formula: C₃₀H₃₄S
• Molecular Weight: 426.666
• Mol file: 130443-18-4.mol

Synonyms:1,3-Bis-(4-tert-butyl-phenyl)-5,6-dimethyl-benzo[c]thiophene

Chemical Property of 1,3-Bis-(4-tert-butyl-phenyl)-5,6-dimethyl-benzo[c]thiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Bis-(4-tert-butyl-phenyl)-5,6-dimethyl-benzo[c]thiophene

There total 4 articles about 1,3-Bis-(4-tert-butyl-phenyl)-5,6-dimethyl-benzo[c]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

[2-(4-tert-Butyl-benzoyl)-4,5-dimethyl-phenyl]-(4-tert-butyl-phenyl)-methanone (130443-11-7) → 1,3-Bis-(4-tert-butyl-phenyl)-5,6-dimethyl-benzo[c]thiophene (130443-18-4)

Guidance literature:

With tetraphosphorus decasulfide; sodium hydrogencarbonate; In acetonitrile; at 30 ℃; for 4h;

DOI:10.1055/s-1990-26976

Reference yield:

(E)-1,4-bis(4-(tert-butyl)phenyl)but-2-ene-1,4-dione (103982-14-5) → 1,3-Bis-(4-tert-butyl-phenyl)-5,6-dimethyl-benzo[c]thiophene (130443-18-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / methanol / 5 h / Heating

2: 90 percent / 85percent H₃PO₄, Ac₂O / 0.17 h / 110 - 130 °C

3: 81 percent / Br₂, KOAc, HOAc / 0.5 h / 116 °C

4: 81 percent / P₄S₁₀, NaHCO₃ / acetonitrile / 4 h / 30 °C

With tetraphosphorus decasulfide; phosphoric acid; bromine; potassium acetate; acetic anhydride; sodium hydrogencarbonate; acetic acid; In methanol; acetonitrile;

DOI:10.1055/s-1990-26976

Reference yield:

1,3-Bis(4-tert-butylphenyl)-5,6-dimethyl-4,7-dihydrobenzofuran (130443-08-2) → 1,3-Bis-(4-tert-butyl-phenyl)-5,6-dimethyl-benzo[c]thiophene (130443-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / Br₂, KOAc, HOAc / 0.5 h / 116 °C

2: 81 percent / P₄S₁₀, NaHCO₃ / acetonitrile / 4 h / 30 °C

With tetraphosphorus decasulfide; bromine; potassium acetate; sodium hydrogencarbonate; acetic acid; In acetonitrile;

DOI:10.1055/s-1990-26976

upstream raw materials:

[2-(4-tert-Butyl-benzoyl)-4,5-dimethyl-phenyl]-(4-tert-butyl-phenyl)-methanone

(E)-1,4-bis(4-(tert-butyl)phenyl)but-2-ene-1,4-dione

1,3-Bis(4-tert-butylphenyl)-5,6-dimethyl-4,7-dihydrobenzofuran

4,5-Bis(4-tert-butylbenzoyl)-1,2-dimethylcyclohexen