2-chloro-1H-imidazo[4,5-b]pyridine hydrochloride

Base Information

• Chemical Name: 2-chloro-1H-imidazo[4,5-b]pyridine hydrochloride
• CAS No.: 104685-82-7
• Molecular Formula: C6H4ClN3^.HCl
• Molecular Weight: 153.571
• Hs Code.: 2933990090
• Mol file: 104685-82-7.mol

Synonyms:1H-Imidazo[4,5-b]pyridine,2-chloro- (9CI);Imidazo[4,5-b]pyridine, 2-chloro- (6CI);2-Chloroimidazo[4,5-b]pyridine;

Chemical Property of 2-chloro-1H-imidazo[4,5-b]pyridine hydrochloride

Chemical Property:

• Boiling Point: 278.3±23.0 °C(Predicted)
• PKA: 2.98±0.20(Predicted)
• PSA: 41.57000
• Density: 1.61±0.1 g/cm3(Predicted)
• LogP: 1.61130
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-1H-imidazo[4,5-b]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-1H-imidazo[4,5-b]pyridine hydrochloride

There total 1 articles about 2-chloro-1H-imidazo[4,5-b]pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dihydro-imidazo[4,5-b]pyridin-2-one (16328-62-4) → 2-chloro-imidazo[4,5-b]pyridine (104685-82-7)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate;

DOI:10.1002/ardp.19572900104

Reference yield:

2-chloro-imidazo[4,5-b]pyridine (104685-82-7) → 1H-Imidazo[4,5-b]pyridine (273-21-2,170245-18-8)

Guidance literature:

With phosphonium iodide; hydrogen iodide;

DOI:10.1002/ardp.19572900104

Reference yield:

2-chloro-imidazo[4,5-b]pyridine (104685-82-7) → 4-[4-{(1H-imidazo[4,5-b]pyridin-2-yl)amino}piperidin-1-yl]benzoic acid (883727-03-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 5 h / 170 °C

2: 226 mg / aq. HBr / 7.5 h / Heating

3: dimethylsulfoxide / 6.5 h / 140 °C

4: NaOH / methanol; tetrahydrofuran; H₂O / 3 h / 40 °C

With sodium hydroxide; hydrogen bromide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2005.10.061

upstream raw materials:

1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Downstream raw materials:

1H-Imidazo[4,5-b]pyridine

4-[4-{(1H-imidazo[4,5-b]pyridin-2-yl)amino}piperidin-1-yl]benzoic acid

tert-butyl (2S)-benzenesulfonylamino-3-[4-[4-{(1H-imidazo[4,5-b]pyridin-2-yl)amino}piperidin-1-yl]benzoylamino]propionate