5-[2-(4-carbamimidoylphenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid ethyl ester

Base Information

• Chemical Name: 5-[2-(4-carbamimidoylphenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid ethyl ester
• CAS No.: 685544-39-2
• Molecular Formula: C₂₂H₃₀N₄O₄
• Molecular Weight: 414.505
• Mol file: 685544-39-2.mol

Synonyms:5-[2-(4-carbamimidoylphenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid ethyl ester

Chemical Property of 5-[2-(4-carbamimidoylphenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[2-(4-carbamimidoylphenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid ethyl ester

There total 13 articles about 5-[2-(4-carbamimidoylphenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-[2-(4-methylsulfanylcarbonimidoyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-5-oxo-pentanoic acid ethyl ester (685544-42-7) → 5-[2-(4-carbamimidoylphenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid ethyl ester (685544-39-2)

Guidance literature:

With ammonium acetate; In methanol; at 20 ℃;

DOI:10.1021/jm030354b

Reference yield:

ethyl glutaroyl chloride (5205-39-0) → 5-[2-(4-carbamimidoylphenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid ethyl ester (685544-39-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / DIEA / dimethylformamide / 4 h / 20 °C

2: H₂S (gas); Et₃N; pyridine / 20 °C

3: acetone / 20 °C

4: NH₄OAc / methanol / 20 °C

With pyridine; hydrogen sulfide; ammonium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm030354b

Reference yield:

8-benzyl-2-oxa-8-aza-spiro[4.5]decane-1,3-dione (34702-66-4) → 5-[2-(4-carbamimidoylphenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid ethyl ester (685544-39-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: Et₃N / dimethylformamide / 20 °C

2.1: 3.40 g / acetic anhydride; NaOAc / 2 h / Heating

3.1: NaBH₄ / methanol / 0 - 20 °C

3.2: NaBH₄; TFA / 0 - 20 °C

3.3: 792 mg / acetonitrile; CH₂Cl₂ / 20 °C

4.1: 74 percent / aq. NH₄OAc; Cd-Pb couple / tetrahydrofuran / 20 °C

5.1: 92 percent / DIEA / dimethylformamide / 4 h / 20 °C

6.1: H₂S (gas); Et₃N; pyridine / 20 °C

7.1: acetone / 20 °C

8.1: NH₄OAc / methanol / 20 °C

With pyridine; sodium tetrahydroborate; 10% Cd/Pd; hydrogen sulfide; ammonium acetate; sodium acetate; acetic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm030354b

upstream raw materials:

5-[2-(4-methylsulfanylcarbonimidoyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-5-oxo-pentanoic acid ethyl ester

ethyl glutaroyl chloride

8-benzyl-2-oxa-8-aza-spiro[4.5]decane-1,3-dione

1-phenylmethyl-4-piperidone