N-(3-(2-(4-morpholinophenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(3-(2-(4-morpholinophenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide
CAS No.:1152473-72-7
Molecular Formula:C₂₃H₂₃N₅O₃S₂
Molecular Weight:481.599
Hs Code.:

Synonyms:N-(3-(2-(4-morpholinophenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(2-(4-morpholinophenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

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Technology Process of N-(3-(2-(4-morpholinophenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

There total 6 articles about N-(3-(2-(4-morpholinophenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 2524-67-6,86759-37-7
4-morpholino-4-yl-phenylamine

: 1293987-57-1
N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-methanesulfonamide

: 1152473-72-7
N-(3-(2-(4-morpholinophenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos; In iso-butanol; at 100 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c00459

Reference yield:

: 1152475-42-7
7-bromo-2-chlorothieno[3,2-d]pyrimidine

: 1152473-72-7
N-(3-(2-(4-morpholinophenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

2: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / iso-butanol / 1 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; potassium carbonate; XPhos; In 1,4-dioxane; iso-butanol; 1: |Suzuki Coupling / 2: |Buchwald-Hartwig Coupling;
DOI:10.1021/acs.jmedchem.1c00459

Reference yield:

: 41102-02-7
7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

: 1152473-72-7
N-(3-(2-(4-morpholinophenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate; N,N-diethylaniline / 5 h / 150 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran; ethanol / 1 h / 20 °C / Inert atmosphere

3: chloranil / benzene / 3 h / Inert atmosphere

4: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

5: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / iso-butanol / 1 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; chloranil; sodium carbonate; potassium carbonate; N,N-diethylaniline; XPhos; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; iso-butanol; benzene; 4: |Suzuki Coupling / 5: |Buchwald-Hartwig Coupling;
DOI:10.1021/acs.jmedchem.1c00459