3-benzyl-2-(2-bromophenylthiomethyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one

Base Information

Chemical Name:3-benzyl-2-(2-bromophenylthiomethyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one
CAS No.:269742-91-8
Molecular Formula:C₂₂H₁₈BrNO₂S
Molecular Weight:440.36
Hs Code.:

Synonyms:3-benzyl-2-(2-bromophenylthiomethyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one

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Chemical Property of 3-benzyl-2-(2-bromophenylthiomethyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one

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Technology Process of 3-benzyl-2-(2-bromophenylthiomethyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one

There total 3 articles about 3-benzyl-2-(2-bromophenylthiomethyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 269742-90-7
N-(2-bromophenylthiomethyl)phthalimide

: 6921-34-2
benzylmagnesium chloride

: 269742-91-8
3-benzyl-2-(2-bromophenylthiomethyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one

Guidance literature:: In diethyl ether; dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ol005545c

Reference yield:

: 17564-64-6
N-(chloromethyl)phthalimide

: 269742-91-8
3-benzyl-2-(2-bromophenylthiomethyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / sodium methylate / dimethylformamide / 5 h / 20 °C

2: 61 percent / CH₂Cl₂; diethyl ether / 3 h / 20 °C

With sodium methylate; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Grignard reaction;
DOI:10.1021/ol005545c

Reference yield:

: 6320-02-1
o-bromothiophenol

: 269742-91-8
3-benzyl-2-(2-bromophenylthiomethyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / sodium methylate / dimethylformamide / 5 h / 20 °C

2: 61 percent / CH₂Cl₂; diethyl ether / 3 h / 20 °C

With sodium methylate; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Grignard reaction;
DOI:10.1021/ol005545c