C₆₃H₁₀₀O₁₁SSi₃

Base Information Edit

Chemical Name:C₆₃H₁₀₀O₁₁SSi₃
CAS No.:214533-41-2
Molecular Formula:C₆₃H₁₀₀O₁₁SSi₃
Molecular Weight:1149.8
Hs Code.:
Mol file:214533-41-2.mol

C<sub>63</sub>H<sub>100</sub>O<sub>11</sub>SSi<sub>3</sub>

Synonyms:C₆₃H₁₀₀O₁₁SSi₃

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Chemical Property of C₆₃H₁₀₀O₁₁SSi₃ Edit

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Technology Process of C₆₃H₁₀₀O₁₁SSi₃

There total 38 articles about C₆₃H₁₀₀O₁₁SSi₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 98-59-9
p-toluenesulfonyl chloride

: 214533-39-8
C₅₆H₉₄O₉Si₃

: 214533-41-2
C₆₃H₁₀₀O₁₁SSi₃

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 27h; Ambient temperature;
DOI:10.1248/cpb.46.1199

Reference yield:

: 186641-79-2
(R)-4-((tert-Butyldiphenylsilyl)oxy)-3-methylbutanal

: 214533-41-2
C₆₃H₁₀₀O₁₁SSi₃

Guidance literature:: Multi-step reaction with 36 steps

1: CH₂Cl₂ / 10 h / Ambient temperature

2: 100 percent / DIBAH / CH₂Cl₂ / 1.5 h / -78 °C

3: 90 percent / (iso-PrO)4Ti, D-(-)-DET, 3A molecular sieves, tert-butylhydroperoxide / CH₂Cl₂; toluene / 8 h / Ambient temperature

4: 93 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran / 30 h / -20 °C

5: 100 percent / p-TsOH*H₂O / benzene / 3 h / Ambient temperature

6: 90 percent / DIBAH / CH₂Cl₂ / 1.5 h / -78 °C

7: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -30 deg C, 1 h

8: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, RT, 1 h

9: 99 percent / LiAlH₄, LiI / diethyl ether / 1 h / -100 °C

10: 89 percent / AcOH, MeOH / 24 h / Ambient temperature

11: 88 percent / NaHCO₃, I₂ / tetrahydrofuran / 0.5 h / 0 °C

12: 90 percent / NaH / tetrahydrofuran / 1 h / Ambient temperature

13: 100 percent / H₂ / Raney-Ni / ethanol / 760 Torr / Ambient temperature

14: 84 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

15: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -78 deg C, 1 h

16: 1.) tert-BuOK / 1.) THF, RT, 1 h, 2.) THF, 0 deg C, 2 h

17: Et₃N, DMAP / CH₂Cl₂ / 1 h / 0 °C

18: 88 percent / TBAF / tetrahydrofuran / 3 h / Ambient temperature

19: Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

20: dimethylsulfoxide / 0.5 h / 50 °C

21: 99 percent / K₂CO₃ / methanol / 4 h / Ambient temperature

22: 97 percent / (iso-Pr)2EtN / CH₂Cl₂ / 2 h / Ambient temperature

23: 1.) DIBAH, 2.) aq. Rochelle salt / 1.) CH₂Cl₂, hexane, -78 deg C, 30 min, 2.) CH₂Cl₂, hexane, RT, 3 h

24: CrO₃, H₂SO₄ / acetone / 0.5 h / 20 °C

25: diethyl ether

26: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 15 min

27: 96 percent / Dess-Martin reagent / CH₂Cl₂ / 0.33 h / Ambient temperature

28: PPTS, MeOH / 6 h / Ambient temperature

29: Et₃N, DMAP / CH₂Cl₂ / 0.25 h / Ambient temperature

30: Et₃SiH, BF₃*Et₂O / acetonitrile / 0.08 h / 0 °C

31: imidazole / CH₂Cl₂ / 0.5 h / 0 °C

32: K₂CO₃ / methanol / 0.25 h / Ambient temperature

33: dl-camphorsulfonic acid / benzene / 0.5 h / 0 °C

34: 89 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

35: 84 percent / DIBAH / hexane; toluene / 0.25 h / -78 °C

36: 100 percent / Et₃N, DMAP / CH₂Cl₂ / 27 h / Ambient temperature

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; chromium(VI) oxide; titanium(IV) isopropylate; methanol; triethylsilane; tert.-butylhydroperoxide; dmap; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; diethyl (2S,3S)-tartrate; 3 A molecular sieve; sulfuric acid; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; iodine; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; rochelle salt; triethylamine; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium iodide; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; dimethyl sulfoxide; acetone; toluene; acetonitrile; benzene;
DOI:10.1248/cpb.46.1199

Reference yield:

: 186641-76-9
(2R)-1-(tert-butyldiphenylsilyloxy)-3-cyano-2-methylpropane

: 214533-41-2
C₆₃H₁₀₀O₁₁SSi₃

Guidance literature:: Multi-step reaction with 37 steps

1: 1.) DIBAH, 2.) aq. HCl, Rochelle salt / 1.) CH₂Cl₂, THF, -78 deg C, 40 min, 2.) CH₂Cl₂, THF, Et₂O, RT, 12 h

2: CH₂Cl₂ / 10 h / Ambient temperature

3: 100 percent / DIBAH / CH₂Cl₂ / 1.5 h / -78 °C

4: 90 percent / (iso-PrO)4Ti, D-(-)-DET, 3A molecular sieves, tert-butylhydroperoxide / CH₂Cl₂; toluene / 8 h / Ambient temperature

5: 93 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran / 30 h / -20 °C

6: 100 percent / p-TsOH*H₂O / benzene / 3 h / Ambient temperature

7: 90 percent / DIBAH / CH₂Cl₂ / 1.5 h / -78 °C

8: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -30 deg C, 1 h

9: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, RT, 1 h

10: 99 percent / LiAlH₄, LiI / diethyl ether / 1 h / -100 °C

11: 89 percent / AcOH, MeOH / 24 h / Ambient temperature

12: 88 percent / NaHCO₃, I₂ / tetrahydrofuran / 0.5 h / 0 °C

13: 90 percent / NaH / tetrahydrofuran / 1 h / Ambient temperature

14: 100 percent / H₂ / Raney-Ni / ethanol / 760 Torr / Ambient temperature

15: 84 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

16: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -78 deg C, 1 h

17: 1.) tert-BuOK / 1.) THF, RT, 1 h, 2.) THF, 0 deg C, 2 h

18: Et₃N, DMAP / CH₂Cl₂ / 1 h / 0 °C

19: 88 percent / TBAF / tetrahydrofuran / 3 h / Ambient temperature

20: Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

21: dimethylsulfoxide / 0.5 h / 50 °C

22: 99 percent / K₂CO₃ / methanol / 4 h / Ambient temperature

23: 97 percent / (iso-Pr)2EtN / CH₂Cl₂ / 2 h / Ambient temperature

24: 1.) DIBAH, 2.) aq. Rochelle salt / 1.) CH₂Cl₂, hexane, -78 deg C, 30 min, 2.) CH₂Cl₂, hexane, RT, 3 h

25: CrO₃, H₂SO₄ / acetone / 0.5 h / 20 °C

26: diethyl ether

27: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 15 min

28: 96 percent / Dess-Martin reagent / CH₂Cl₂ / 0.33 h / Ambient temperature

29: PPTS, MeOH / 6 h / Ambient temperature

30: Et₃N, DMAP / CH₂Cl₂ / 0.25 h / Ambient temperature

31: Et₃SiH, BF₃*Et₂O / acetonitrile / 0.08 h / 0 °C

32: imidazole / CH₂Cl₂ / 0.5 h / 0 °C

33: K₂CO₃ / methanol / 0.25 h / Ambient temperature

34: dl-camphorsulfonic acid / benzene / 0.5 h / 0 °C

35: 89 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

36: 84 percent / DIBAH / hexane; toluene / 0.25 h / -78 °C

37: 100 percent / Et₃N, DMAP / CH₂Cl₂ / 27 h / Ambient temperature

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; chromium(VI) oxide; titanium(IV) isopropylate; hydrogenchloride; methanol; triethylsilane; tert.-butylhydroperoxide; dmap; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; diethyl (2S,3S)-tartrate; 3 A molecular sieve; sulfuric acid; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; iodine; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; rochelle salt; triethylamine; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium iodide; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; dimethyl sulfoxide; acetone; toluene; acetonitrile; benzene;
DOI:10.1248/cpb.46.1199