4'-chloro-6-methyl-biphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide

Base Information

Chemical Name:4'-chloro-6-methyl-biphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide
CAS No.:1000588-32-8
Molecular Formula:C₂₃H₂₁ClN₂O
Molecular Weight:376.886
Hs Code.:

Synonyms:4'-chloro-6-methyl-biphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide

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Chemical Property of 4'-chloro-6-methyl-biphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide

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Technology Process of 4'-chloro-6-methyl-biphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide

There total 4 articles about 4'-chloro-6-methyl-biphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {5-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid methyl ester

: 1000588-32-8
4'-chloro-6-methyl-biphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide

Guidance literature:: With trimethylsilyl iodide; In acetonitrile; at 20 ℃;
DOI:10.1021/jm010294e

Reference yield:

: 131001-86-0
methyl 2-bromo-3-methylbenzoate

: 1000588-32-8
4'-chloro-6-methyl-biphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: PdCl₂(dppf); K₃PO₄ / 1,2-dimethoxy-ethane / 16 h / Heating

2: 1 N aq. NaOH / ethanol / 5 h / Heating

3: oxalyl chloride; DMF / CH₂Cl₂ / 16 h / 20 °C

4: pyridine / CH₂Cl₂ / 0.25 h

5: Me₃SiI / acetonitrile / 20 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide; potassium phosphate; oxalyl dichloride; trimethylsilyl iodide; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; ethanol; dichloromethane; acetonitrile; 1: Suzuki coupling;
DOI:10.1021/jm010294e

Reference yield:

: 474520-25-7
4'-chloro-6-methyl-biphenyl-2-carboxylic acid

: 1000588-32-8
4'-chloro-6-methyl-biphenyl-2-carboxylic acid (2-amino-indan-5-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 16 h / 20 °C

2: pyridine / CH₂Cl₂ / 0.25 h

3: Me₃SiI / acetonitrile / 20 °C

With pyridine; oxalyl dichloride; trimethylsilyl iodide; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;
DOI:10.1021/jm010294e