tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate

Base Information

Chemical Name:tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate
CAS No.:223697-44-7
Molecular Formula:C₃₁H₄₆N₄O₈
Molecular Weight:602.728
Hs Code.:

tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate

Synonyms:tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate

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Chemical Property of tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate

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Technology Process of tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate

There total 8 articles about tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 169498-28-6
(3R)-1-{3-[1-(tert-butoxycarbonyl)-4-piperidinyl]propanoyl}-3-piperidinecarboxylic acid

: 35761-27-4,96192-93-7
methyl (2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoate hydrochloride

: 223697-44-7
tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 4 ℃;
DOI:10.1016/j.bmc.2005.03.056

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 223697-44-7
tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran / 1 h / 15 - 20 °C

1.2: 78 percent / tetrahydrofuran / 20 °C

2.1: 88 percent / HCl; H₂ / PtO₂ / ethanol; dioxane / 5 h / 45 °C

3.1: 81 percent / triethylamine / CH₂Cl₂ / 5 h / 20 °C

4.1: 91 percent / aq. NaOH / tetrahydrofuran; ethanol / 2 h / 20 °C

5.1: 86 percent / 1-hydroxybenzotriazole; EDC / dimethylformamide / 20 °C

6.1: 90 percent / aq. LiOH / tetrahydrofuran; ethanol / 1 h / 20 °C

7.1: 93 percent / 1-hydroxybenzotriazole; EDC / dimethylformamide / 4 °C

With hydrogenchloride; lithium hydroxide; sodium hydroxide; hydrogen; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.03.056

Reference yield:

: 123293-78-7
ethyl 3-(4-pyridinyl)-(2E)-propenoate

: 223697-44-7
tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / HCl; H₂ / PtO₂ / ethanol; dioxane / 5 h / 45 °C

2: 81 percent / triethylamine / CH₂Cl₂ / 5 h / 20 °C

3: 91 percent / aq. NaOH / tetrahydrofuran; ethanol / 2 h / 20 °C

4: 86 percent / 1-hydroxybenzotriazole; EDC / dimethylformamide / 20 °C

5: 90 percent / aq. LiOH / tetrahydrofuran; ethanol / 1 h / 20 °C

6: 93 percent / 1-hydroxybenzotriazole; EDC / dimethylformamide / 4 °C

With hydrogenchloride; lithium hydroxide; sodium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.03.056