(E)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene

Base Information

Chemical Name:(E)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene
CAS No.:124688-03-5
Molecular Formula:C₂₀H₂₀O₂
Molecular Weight:292.378
Hs Code.:

Synonyms:(E)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene

Suppliers and Price of (E)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(E)-1-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)-2,3-dihydro-6-methoxy-1H-indene
100mg
$ 495.00

Medical Isotopes, Inc.
(E)-1-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)-2,3-dihydro-6-methoxy-1H-indene
250 mg
$ 1400.00

Medical Isotopes, Inc.
(E)-1-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)-2,3-dihydro-6-methoxy-1H-indene
100 mg
$ 950.00

Total 2 raw suppliers

Chemical Property of (E)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(E)-1-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)-2,3-dihydro-6-methoxy-1H-indene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (E)-1-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)-2,3-dihydro-6-methoxy-1H-indene is an by-product formed in the synthesis of Fadolmidine (F101040), a novel α2-adrenoceptor (α2-AR) agonist that exhibits antinociception properties.

Technology Process of (E)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene

There total 3 articles about (E)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: (Z)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene

: 124688-03-5
(E)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene

Guidance literature:: With titanium tetrachloride; zinc; In tetrahydrofuran; for 0.583333h; Reflux;
DOI:10.1021/ja301928d

Reference yield: 55.0%

: 124688-02-4
6-methoxy-2,3-dihydrospiro[Indene-1,2’-[1,3]dithiolane]

: 782-06-9
(E)-2,3-diphenylbutene

: 124688-03-5
(E)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene

Guidance literature:: With tungsten hexacarbonyl; In chlorobenzene; at 160 ℃; for 24h; Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00293a037

Reference yield:

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: 124688-03-5
(E)-6,6'-dimethoxy-2,2',3,3'-tetrahydro-1,1'-biindenylidene

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride etherate / CHCl₃ / 3 h / Heating

2: 55 percent / W(CO)6 / chlorobenzene / 24 h / 160 °C

With tungsten hexacarbonyl; boron trifluoride diethyl etherate; In chloroform; chlorobenzene;
DOI:10.1021/jo00293a037