N²-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O⁶-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine

Base Information

• Chemical Name: N²-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O⁶-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine
• CAS No.: 908371-59-5
• Molecular Formula: C₃₃H₅₀N₆O₈SeSi₂
• Molecular Weight: 793.926

Synonyms:N²-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O⁶-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine

Chemical Property of N²-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O⁶-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O⁶-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine

There total 7 articles about N²-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O⁶-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N2-acetyl-9-{2'-O-[(trifluoromethyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl}-O6-[2-(4-nitrophenyl)ethyl]guanine (908371-60-8) + dimethyl diselenide (7101-31-7) → N2-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O6-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine (908371-59-5)

Guidance literature:

dimethyl diselenide; With sodium tetrahydroborate; ethanol; In tetrahydrofuran; at 20 ℃; for 1h;

N²-acetyl-9-{2'-O-[(trifluoromethyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl}-O⁶-[2-(4-nitrophenyl)ethyl]guanine; In tetrahydrofuran; at 20 ℃; for 0.333333h;

DOI:10.1021/ja0621400

Reference yield:

9-β-D-arabinofuranosylguanine (38819-10-2) → N2-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O6-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine (908371-59-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 98 percent / pyridine / dimethylformamide / 16 h / 20 °C

2.1: 2.91 g / pyridine / dimethylformamide / 16 h / 80 °C

3.1: triphenylphosphine / dioxane / 0.5 h

3.2: 64 percent / diisopropyl azodicarboxylate / dioxane / 0.75 h

4.1: 57 percent / aq. NaOH / tetrahydrofuran; methanol / 0.12 h / 0 °C

5.1: 69 percent / triethylamine; DMAP / CH₂Cl₂ / 2 h / 0 °C

6.1: sodium borohydride; ethanol / tetrahydrofuran / 1 h / 20 °C

6.2: 87 percent / tetrahydrofuran / 0.33 h / 20 °C

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; ethanol; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja0621400

Reference yield:

N2-acetyl-9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]-O6-[2-(4-nitrophenyl)ethyl]guanine (908371-55-1) → N2-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O6-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine (908371-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 69 percent / triethylamine; DMAP / CH₂Cl₂ / 2 h / 0 °C

2.1: sodium borohydride; ethanol / tetrahydrofuran / 1 h / 20 °C

2.2: 87 percent / tetrahydrofuran / 0.33 h / 20 °C

With dmap; sodium tetrahydroborate; ethanol; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja0621400

upstream raw materials:

N²-acetyl-9-{2'-O-[(trifluoromethyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl}-O⁶-[2-(4-nitrophenyl)ethyl]guanine

dimethyl diselenide

N²-acetyl-9-[2'-O-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]guanine

N²-acetyl-9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]-O⁶-[2-(4-nitrophenyl)ethyl]guanine

Downstream raw materials:

N²-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-methylselenoguanosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 908371-59-5 N²-acetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-O⁶-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2'-methylselenoguanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send