2-methylene-4-nitro-3-phenylpentanedioic acid 5-ethyl ester 1-methyl ester

Base Information

Chemical Name:2-methylene-4-nitro-3-phenylpentanedioic acid 5-ethyl ester 1-methyl ester
CAS No.:896710-26-2
Molecular Formula:C₁₅H₁₇NO₆
Molecular Weight:307.303
Hs Code.:

Synonyms:2-methylene-4-nitro-3-phenylpentanedioic acid 5-ethyl ester 1-methyl ester

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Chemical Property of 2-methylene-4-nitro-3-phenylpentanedioic acid 5-ethyl ester 1-methyl ester

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Technology Process of 2-methylene-4-nitro-3-phenylpentanedioic acid 5-ethyl ester 1-methyl ester

There total 2 articles about 2-methylene-4-nitro-3-phenylpentanedioic acid 5-ethyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 626-35-7
nitroacetic acid ethyl ester

: 103669-71-2
(Z)-methyl 2-(bromomethyl)-3-phenylacrylate

: 896710-26-2
2-methylene-4-nitro-3-phenylpentanedioic acid 5-ethyl ester 1-methyl ester

Guidance literature:: (Z)-methyl 2-(bromomethyl)-3-phenylacrylate; With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

nitroacetic acid ethyl ester; In tetrahydrofuran; water; at 20 ℃; for 48h;
DOI:10.1016/j.tetlet.2006.03.167

Reference yield:

: 18020-59-2
methyl 3-hydroxy-2-methylidene-3-phenylpropionate

: 896710-26-2
2-methylene-4-nitro-3-phenylpentanedioic acid 5-ethyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 3 h / 20 °C

2: 77 percent / DABCO / tetrahydrofuran; H₂O / 4 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2006.08.045