(R)-2-Benzyl-N¹-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N⁴-(2-methoxymethoxy-ethyl)-N⁴-methyl-succinamide

Base Information

• Chemical Name: (R)-2-Benzyl-N¹-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N⁴-(2-methoxymethoxy-ethyl)-N⁴-methyl-succinamide
• CAS No.: 127944-53-0
• Molecular Formula: C₃₆H₅₄N₆O₈
• Molecular Weight: 698.86

Synonyms:(R)-2-Benzyl-N¹-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N⁴-(2-methoxymethoxy-ethyl)-N⁴-methyl-succinamide

Chemical Property of (R)-2-Benzyl-N¹-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N⁴-(2-methoxymethoxy-ethyl)-N⁴-methyl-succinamide

Chemical Property:

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Technology Process of (R)-2-Benzyl-N¹-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N⁴-(2-methoxymethoxy-ethyl)-N⁴-methyl-succinamide

There total 9 articles about (R)-2-Benzyl-N¹-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N⁴-(2-methoxymethoxy-ethyl)-N⁴-methyl-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-tert-Butoxycarbonylamino-3-(3H-imidazol-4-yl)-propionic acid (17791-52-5) → (R)-2-Benzyl-N1-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N4-(2-methoxymethoxy-ethyl)-N4-methyl-succinamide (127944-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 16 h

2: ethanolic HCl / 1 h

3: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 16 h

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00169a024

Reference yield:

1-(methoxymethoxy)-2-(methylamino)ethane (122225-44-9) → (R)-2-Benzyl-N1-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N4-(2-methoxymethoxy-ethyl)-N4-methyl-succinamide (127944-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) CH₂Cl₂, -10 deg C, 3 min, 2a.) -10 deg, 15 min, 2b.) RT, 2 h

2: 100 percent / H₂ / 10percent Pd/C / methanol / 1 h

3: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 16 h

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isobutyl chloroformate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00169a024

Reference yield:

2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane (122225-41-6) → (R)-2-Benzyl-N1-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N4-(2-methoxymethoxy-ethyl)-N4-methyl-succinamide (127944-53-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / H₂ / 10percent Pd/C / methanol / 12 h

2: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) CH₂Cl₂, -10 deg C, 3 min, 2a.) -10 deg, 15 min, 2b.) RT, 2 h

3: 100 percent / H₂ / 10percent Pd/C / methanol / 1 h

4: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 16 h

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isobutyl chloroformate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00169a024

upstream raw materials:

(2R)-2-benzyl-3-<<<2-(methoxymethoxy)ethyl>methylamino>carbonyl>propionic acid

(S)-2-Amino-N-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethyl]-3-(3H-imidazol-4-yl)-propionamide

1-(methoxymethoxy)-2-(methylamino)ethane

2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane

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