ethyl 6-ethyl-2-Methyl-4-oxocyclohex-2-enecarboxylate

Base Information

• Chemical Name: ethyl 6-ethyl-2-Methyl-4-oxocyclohex-2-enecarboxylate
• CAS No.: 5421-90-9
• Molecular Formula: C12H18 O3
• Molecular Weight: 210.273
• Hs Code.: 2918300090
• Mol file: 5421-90-9.mol

Synonyms:NSC5688; NSC 57312

Chemical Property of ethyl 6-ethyl-2-Methyl-4-oxocyclohex-2-enecarboxylate

Chemical Property:

• Vapor Pressure: 0.00132mmHg at 25°C
• Boiling Point: 297.8°Cat760mmHg
• Flash Point: 127.2°C
• PSA: 43.37000
• Density: 1.021g/cm³
• LogP: 2.11100

Purity/Quality:

99%min ^*data from raw suppliers

Ethyl6-ethyl-2-methyl-4-oxocyclohex-2-enecarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 6-ethyl-2-Methyl-4-oxocyclohex-2-enecarboxylate

There total 7 articles about ethyl 6-ethyl-2-Methyl-4-oxocyclohex-2-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl acetoacetate (141-97-9) + propionaldehyde (123-38-6) → 6-ethyl-2-methyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester (5421-90-9)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 80 ℃; for 12h;

DOI:10.1016/j.tetlet.2017.04.090

Reference yield: 31.0%

5-acetyl-4-ethyl-1,2,6-trimethyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester → 6-ethyl-4-methyl-2-oxo-cyclohex-3-enecarboxylic acid ethyl ester + 6-ethyl-4-methyl-2-oxo-cyclohex-3-enecarboxylic acid ethyl ester + 3-methyl-5-ethylcyclohex-2-en-1-one (40920-68-1) + 6-ethyl-2-methyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester (5421-90-9)

Guidance literature:

With hydrogenchloride; In ethanol; for 4h; Heating;

DOI:10.1007/s10593-007-0006-0

Reference yield:

2-acetyl-pent-2-enoic acid ethyl ester (3885-50-5) → 6-ethyl-2-methyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester (5421-90-9)

Guidance literature:

at 130 ℃; for 5h;

DOI:10.1007/s11172-015-0873-y

upstream raw materials:

ethyl acetoacetate

propionaldehyde

2-acetyl-pent-2-enoic acid ethyl ester

Downstream raw materials:

4-acetylamino-2-ethyl-6-methyl-benzoic acid

3-methyl-5-ethylcyclohex-2-en-1-one

Refernces

• 1、 Kang, Sein,Kim, Dahye,In, Ik Joon,Koo, Sangho. "Efficient preparation method of 4-hydroxybenzoic esters – Oxidation of substituted Hagemman's ester". . p. 2264 - 2266. Retrieved 2018/03/26.
• 2、 Ramachary, Dhevalapally B.,Narayana, Vidadala V.,Prasad, M. Shiva,Ramakumar, Kinthada. "High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations". body text. p. 3372 - 3378. Retrieved 2010/01/06.