tert-butyl 3-(5-(5-amino-2-methylbenzamido)pyrimidin-2-ylamino)phenylcarbamate

Base Information

• Chemical Name: tert-butyl 3-(5-(5-amino-2-methylbenzamido)pyrimidin-2-ylamino)phenylcarbamate
• CAS No.: 1613228-52-6
• Molecular Formula: C₂₃H₂₆N₆O₃
• Molecular Weight: 434.498

Synonyms:tert-butyl 3-(5-(5-amino-2-methylbenzamido)pyrimidin-2-ylamino)phenylcarbamate

Chemical Property of tert-butyl 3-(5-(5-amino-2-methylbenzamido)pyrimidin-2-ylamino)phenylcarbamate

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Technology Process of tert-butyl 3-(5-(5-amino-2-methylbenzamido)pyrimidin-2-ylamino)phenylcarbamate

There total 10 articles about tert-butyl 3-(5-(5-amino-2-methylbenzamido)pyrimidin-2-ylamino)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl (3-((5-(2-methyl-5-nitrobenzamido)pyrimidin-2-yl)amino)phenyl)carbamate → tert-butyl 3-(5-(5-amino-2-methylbenzamido)pyrimidin-2-ylamino)phenylcarbamate (1613228-52-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; at 20 ℃;

DOI:10.1016/j.ejmech.2021.114051

Reference yield: 85.0%

C38H36N6O5 → tert-butyl 3-(5-(5-amino-2-methylbenzamido)pyrimidin-2-ylamino)phenylcarbamate (1613228-52-6)

Guidance literature:

With morpholine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 53.0%

C31H32N6O5 (1613228-54-8) → tert-butyl 3-(5-(5-amino-2-methylbenzamido)pyrimidin-2-ylamino)phenylcarbamate (1613228-52-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 60 ℃; for 10h;

DOI:10.1021/jm4017762

upstream raw materials:

tert-butyl 3-(5-aminopyrimidin-2-ylamino)phenylcarbamate

C₃₁H₃₂N₆O₅

(3-aminophenyl)carbamic acid tert-butyl ester

tert-butyl (3-((5-nitropyrimidin-2-yl)amino)phenyl)carbamate

Downstream raw materials:

N-(2-(3-aminophenylamino)pyrimidin-5-yl)-2-methyl-5-propionamidobenzamide

N-(2-(3-aminophenylamino)pyrimidin-5-yl)-5-(cyclopropanecarboxamido)-2-methylbenzamide

N-(2-(3-aminophenylamino)pyrimidin-5-yl)-5-(3-chlorobenzamido)-2-methylbenzamide

N-(2-(3-aminophenylamino)pyrimidin-5-yl)-5-(3-(dimethylamino)benzamido)-2-methylbenzamide

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