(2S)-(1-tert-butyldimethylsilyloxy-5-methylhex-5-en-2-yl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Base Information

Chemical Name:(2S)-(1-tert-butyldimethylsilyloxy-5-methylhex-5-en-2-yl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
CAS No.:1403876-12-9
Molecular Formula:C₂₃H₃₅F₃O₄Si
Molecular Weight:460.609
Hs Code.:

Synonyms:(2S)-(1-tert-butyldimethylsilyloxy-5-methylhex-5-en-2-yl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-(1-tert-butyldimethylsilyloxy-5-methylhex-5-en-2-yl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Technology Process of (2S)-(1-tert-butyldimethylsilyloxy-5-methylhex-5-en-2-yl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 4 articles about (2S)-(1-tert-butyldimethylsilyloxy-5-methylhex-5-en-2-yl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1403876-11-8
(2S)-1-tert-butyldimethylsilyloxy-5-methylhex-5-en-2-ol

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 1403876-12-9
(2S)-(1-tert-butyldimethylsilyloxy-5-methylhex-5-en-2-yl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: With pyridine; 1-amino-3-(dimethylamino)propane; In tetrachloromethane; at 20 ℃; for 16h;
DOI:10.1039/c2ob26310f

Reference yield:

: 396092-18-5
(2S)-5-methyl-4-(phenylsulfonyl)hex-5-ene-1,2-diol

: 1403876-12-9
(2S)-(1-tert-butyldimethylsilyloxy-5-methylhex-5-en-2-yl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole; dmap / dichloromethane / 6 h / 0 - 20 °C

2: 2,2'-azobis(isobutyronitrile) / benzene / 1.5 h / Reflux

3: silica gel / dichloromethane / 4 h / 20 °C

4: pyridine; 1-amino-3-(dimethylamino)propane / tetrachloromethane / 16 h / 20 °C

With pyridine; 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); silica gel; 1-amino-3-(dimethylamino)propane; In tetrachloromethane; dichloromethane; benzene;
DOI:10.1039/c2ob26310f

Reference yield:

: 396092-19-6
(2S)-1-tert-butyldimethylsilyloxy-5-methyl-4-(phenylsulfonyl)hex-5-en-2-ol

: 1403876-12-9
(2S)-(1-tert-butyldimethylsilyloxy-5-methylhex-5-en-2-yl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,2'-azobis(isobutyronitrile) / benzene / 1.5 h / Reflux

2: silica gel / dichloromethane / 4 h / 20 °C

3: pyridine; 1-amino-3-(dimethylamino)propane / tetrachloromethane / 16 h / 20 °C

With pyridine; 2,2'-azobis(isobutyronitrile); silica gel; 1-amino-3-(dimethylamino)propane; In tetrachloromethane; dichloromethane; benzene;
DOI:10.1039/c2ob26310f