(R)-1-(3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:(R)-1-(3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione
CAS No.:1198222-50-2
Molecular Formula:C₂₄H₂₇N₃O₅S
Molecular Weight:469.561
Hs Code.:

Synonyms:(R)-1-(3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione

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Chemical Property of (R)-1-(3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione

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Technology Process of (R)-1-(3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione

There total 5 articles about (R)-1-(3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.4%

: 1198225-45-4
(R)-1-(3-bromopropylsulfonyl)-2-((tert-butyldimethylsilyloxy)diphenylmethyl)pyrrolidine

: 10457-14-4
O,O'-bis-(trimethylsilyl)uracil

: 1198222-50-2
(R)-1-(3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: (R)-1-(3-bromopropylsulfonyl)-2-((tert-butyldimethylsilyloxy)diphenylmethyl)pyrrolidine; O,O'-bis-(trimethylsilyl)uracil; With iodine; In 1,2-dichloro-ethane; at 93 ℃; for 10h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: (R)-3-benzoyl-1-(3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione

: 1198222-50-2
(R)-1-(3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With methylamine; Triphenylphosphine oxide; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jm201627n

Reference yield:

: 1370293-21-2
(R)-(1-(3-chloropropylsulfonyl)pyrrolidin-2-yl)diphenylmethanol

: 1198222-50-2
(R)-1-(3-(2-(hydroxydiphenylmethyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide / N,N-dimethyl-formamide / 12 h / 90 °C

2: methylamine / methanol / 1 h / 20 °C

3: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 2 h / 20 °C

4: methylamine; Triphenylphosphine oxide / methanol / 1 h / 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; methylamine; Triphenylphosphine oxide; sodium iodide; In methanol; N,N-dimethyl-formamide; toluene; 3: Mitsunobu reaction;
DOI:10.1021/jm201627n