(+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol

Base Information

Chemical Name:(+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol
CAS No.:110864-99-8
Molecular Formula:C₁₂H₁₃F₂N₃O₆
Molecular Weight:333.249
Hs Code.:

Synonyms:(+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol

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Technology Process of (+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol

There total 3 articles about (+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 123169-16-4
(+/-)-(6aα,8β,9aβ)-9,9-difluorohexahydro-8-<2,4-dinitrophenyl)amino>-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin

: 110864-99-8
(+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;
DOI:10.1021/jm00163a030

Reference yield:

: 110864-89-6
(1RS,8RS,10RS,11SR)-10-(2,4-dinitroanilino)-3,3,5,5-tetraisopropyl-2,4,6-trioxa-3,5-disilabicyclo<6.3.0>undecan-11-ol

: 110864-99-8
(+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 17 percent / 1.) dicyclohexylcarbodiimide, H₃PO₄, 2.) ethyl acetate, oxalic acid / 1.) DMSO, RT, 3.5 h, 2.) methanol, RT, 5 min

2: 25 percent / (diethylamino)sulfur trifluoride / CH₂Cl₂ / 1 h / 5 °C

3: 25 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

With diethylamino-sulfur trifluoride; phosphoric acid; tetrabutyl ammonium fluoride; oxalic acid; ethyl acetate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00163a030

Reference yield:

: 110880-87-0
(+/-)-(6aα,8β,9aβ)-8-<2,4-dinitrophenyl)amino>hexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin-9-one

: 110864-99-8
(+/-)-(1α,2β,4α)-4-<(2,4-dinitrophenyl)amino>-3,3-difluoro-2-hyrroxycyclopentanemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 25 percent / (diethylamino)sulfur trifluoride / CH₂Cl₂ / 1 h / 5 °C

2: 25 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

With diethylamino-sulfur trifluoride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00163a030