(1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-2H-chromen-4-yl)methanol

Base Information

• Chemical Name: (1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-2H-chromen-4-yl)methanol
• CAS No.: 1160309-82-9
• Molecular Formula: C₂₈H₂₇NO₃
• Molecular Weight: 425.527

Synonyms:(1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-2H-chromen-4-yl)methanol

Chemical Property of (1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-2H-chromen-4-yl)methanol

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Technology Process of (1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-2H-chromen-4-yl)methanol

There total 1 articles about (1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-2H-chromen-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4-bromo-7-methoxy-2,2-dimethyl-2H-chromene (128935-26-2) + 1-benzylindole-2-carbaldehyde (81787-94-2) → (1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-2H-chromen-4-yl)methanol (1160309-82-9)

Guidance literature:

4-bromo-7-methoxy-2,2-dimethyl-2H-chromene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

1-benzylindole-2-carbaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1039/b901632e

Reference yield: 91.0%

(1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-2H-chromen-4-yl)methanol (1160309-82-9) → (+/-)-11-benzyl-3-methoxy-6,6-dimethyl-6a,11-dihydro-6H-5-oxa-11-azabenzo[5,6]pentaleno[2,1-b]naphthalene (1314683-80-1)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 0.0166667h; Inert atmosphere;

DOI:10.1039/c0ob00892c

Reference yield: 77.0%

(1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-2H-chromen-4-yl)methanol (1160309-82-9) → 2H-chromen(1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-4-yl)methanone (1160309-92-1)

Guidance literature:

With manganese(IV) oxide; In diethyl ether; at 20 ℃; for 2h;

DOI:10.1039/b901632e

upstream raw materials:

4-bromo-7-methoxy-2,2-dimethyl-2H-chromene

1-benzylindole-2-carbaldehyde

Downstream raw materials:

2H-chromen(1-benzyl-1H-indol-2-yl)(7-methoxy-2,2-dimethyl-4-yl)methanone

(+/-)-11-benzyl-3-methoxy-6,6-dimethyl-6a,11-dihydro-6H-5-oxa-11-azabenzo[5,6]pentaleno[2,1-b]naphthalene

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