N-phenyl-N-(2,4-dimethoxybenzyl)-1,1-difluoro-1-phenylmethanesulfonamide

Base Information

• Chemical Name: N-phenyl-N-(2,4-dimethoxybenzyl)-1,1-difluoro-1-phenylmethanesulfonamide
• CAS No.: 803728-04-3
• Molecular Formula: C₂₂H₂₁F₂NO₄S
• Molecular Weight: 433.476

Synonyms:N-phenyl-N-(2,4-dimethoxybenzyl)-1,1-difluoro-1-phenylmethanesulfonamide

Chemical Property of N-phenyl-N-(2,4-dimethoxybenzyl)-1,1-difluoro-1-phenylmethanesulfonamide

Chemical Property:

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Technology Process of N-phenyl-N-(2,4-dimethoxybenzyl)-1,1-difluoro-1-phenylmethanesulfonamide

There total 4 articles about N-phenyl-N-(2,4-dimethoxybenzyl)-1,1-difluoro-1-phenylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-phenyl-N-(2,4-dimethoxybenzyl)-1-phenylmethanesulfonamide (803727-95-9) → N-phenyl-N-(2,4-dimethoxybenzyl)-1,1-difluoro-1-phenylmethanesulfonamide (803728-04-3)

Guidance literature:

With sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/ol048249z

Reference yield:

aniline (62-53-3) → N-phenyl-N-(2,4-dimethoxybenzyl)-1,1-difluoro-1-phenylmethanesulfonamide (803728-04-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / DMAP / tetrahydrofuran / 0 - 20 °C

2: 75 percent / N-fluorobenzenesulfonimide; NaHMDS / tetrahydrofuran / -78 - 20 °C

With dmap; sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran;

DOI:10.1021/ol048249z

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → N-phenyl-N-(2,4-dimethoxybenzyl)-1,1-difluoro-1-phenylmethanesulfonamide (803728-04-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / DMAP / tetrahydrofuran / 0 - 20 °C

2: 75 percent / N-fluorobenzenesulfonimide; NaHMDS / tetrahydrofuran / -78 - 20 °C

With dmap; sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran;

DOI:10.1021/ol048249z

upstream raw materials:

N-phenyl-N-(2,4-dimethoxybenzyl)-1-phenylmethanesulfonamide

aniline

2,4-Dimethoxybenzaldehyde

N-{[2,4-bis(methyloxy)phenyl]methyl}aniline

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