4-(4-isopropylsulfanyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(4-isopropylsulfanyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 478958-03-1
• Molecular Formula: C₂₀H₂₉NO₃S
• Molecular Weight: 363.521

Synonyms:4-(4-isopropylsulfanyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(4-isopropylsulfanyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-(4-isopropylsulfanyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 4-(4-isopropylsulfanyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-propanethiol (75-33-2) + tert-butyl 1-[4-(4-fluorobenzoyl)piperidin-1-yl]carboxylate (160296-40-2) → 4-(4-isopropylsulfanyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester (478958-03-1)

Guidance literature:

2-propanethiol; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

tert-butyl 1-[4-(4-fluorobenzoyl)piperidin-1-yl]carboxylate; In N,N-dimethyl-formamide; at 65 ℃; for 6h; Further stages.;

DOI:10.1021/jm0255163

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-(4-isopropylsulfanyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester (478958-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 97 percent / aq. NaOH / diethyl ether / 0 - 20 °C

2.1: NaH / dimethylformamide / 0 - 20 °C

2.2: 89 percent / dimethylformamide / 6 h / 65 °C

With sodium hydroxide; sodium hydride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jm0255163

Reference yield: 95.0%

methyllithium (917-54-4) + 4-(4-isopropylsulfanyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester (478958-03-1) → 4-[1-hydroxy-1-(4-isopropylsulfanyl-phenyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester (478958-12-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

DOI:10.1021/jm0255163

upstream raw materials:

2-propanethiol

tert-butyl 1-[4-(4-fluorobenzoyl)piperidin-1-yl]carboxylate

di-tert-butyl dicarbonate

Downstream raw materials:

4-[1-hydroxy-1-(4-isopropylsulfanyl-phenyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester

4-[1-(4-isopropylsulfanyl-phenyl)-ethylidene]-piperidine

4-{1-[4-(propane-2-sulfinyl)-phenyl]-ethylidene}-[1,4']bipiperidinyl

4-{1-[4-(propane-2-sulfonyl)-phenyl]-ethylidene}-[1,4']bipiperidinyl

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