N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyI]-1,1,5-trioxo-1λ6-[1,4]thiazepan-6-yl}-benzamide

Base Information

• Chemical Name: N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyI]-1,1,5-trioxo-1λ6-[1,4]thiazepan-6-yl}-benzamide
• CAS No.: 635706-30-8
• Molecular Formula: C₂₀H₂₅N₃O₈S
• Molecular Weight: 467.5
• Mol file: 635706-30-8.mol

Synonyms:N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyI]-1,1,5-trioxo-1λ6-[1,4]thiazepan-6-yl}-benzamide

Chemical Property of N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyI]-1,1,5-trioxo-1λ6-[1,4]thiazepan-6-yl}-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyI]-1,1,5-trioxo-1λ6-[1,4]thiazepan-6-yl}-benzamide

There total 8 articles about N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyI]-1,1,5-trioxo-1λ6-[1,4]thiazepan-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-5-oxo-1-[1,4]thiazepan-6-yl}-benzamide (635706-28-4) → N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyI]-1,1,5-trioxo-1λ6-[1,4]thiazepan-6-yl}-benzamide (635706-30-8)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

allyl [(3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl]carbamate (192760-09-1) → N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyI]-1,1,5-trioxo-1λ6-[1,4]thiazepan-6-yl}-benzamide (635706-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (Ph₃P)4Pd; 1,3-dimethylbarbituric acid / CH₂Cl₂

1.2: HOBT; EDCI / CH₂Cl₂

2.1: mCPBA; NaHCO₃ / CH₂Cl₂

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2006.07.016

Reference yield:

((R)-6-amino-5-oxo-[1,4]thiazepa-4-yl)-acetic acid ethyl ester (161182-12-3) → N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyI]-1,1,5-trioxo-1λ6-[1,4]thiazepan-6-yl}-benzamide (635706-30-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: aq. LiOH / tetrahydrofuran

2.1: (Ph₃P)4Pd; 1,3-dimethylbarbituric acid / CH₂Cl₂

2.2: HOBT; EDCI / CH₂Cl₂

3.1: mCPBA; NaHCO₃ / CH₂Cl₂

With lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2006.07.016

upstream raw materials:

N-{(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-5-oxo-1-[1,4]thiazepan-6-yl}-benzamide

allyl [(3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl]carbamate

((R)-6-amino-5-oxo-[1,4]thiazepa-4-yl)-acetic acid ethyl ester

((R)-6-tert-butoxycarbonylamino-5-oxo-[1,4]thiazepa-4-yl)-acetic acid ethyl ester