3-Methoxy-17α-<1'H-4'-(4-methoxyphenyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol

Base Information

• Chemical Name: 3-Methoxy-17α-<1'H-4'-(4-methoxyphenyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol
• CAS No.: 95846-60-9
• Molecular Formula: C₂₉H₃₅N₃O₃S
• Molecular Weight: 505.681

Synonyms:3-Methoxy-17α-<1'H-4'-(4-methoxyphenyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol

Chemical Property of 3-Methoxy-17α-<1'H-4'-(4-methoxyphenyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol

Chemical Property:

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Technology Process of 3-Methoxy-17α-<1'H-4'-(4-methoxyphenyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol

There total 3 articles about 3-Methoxy-17α-<1'H-4'-(4-methoxyphenyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-methoxyphenyl)-3'-thiosemicarbazide (95846-54-1) → 3-Methoxy-17α-<1'H-4'-(4-methoxyphenyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol (95846-60-9)

Guidance literature:

With sodium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1002/jhet.5570210539

Reference yield:

<17β-Hydroxy-3-methoxy-oestra-1,3,5(10)-trien-17α-yl>-essigsaeure-aethylester (2445-35-4) → 3-Methoxy-17α-<1'H-4'-(4-methoxyphenyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol (95846-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / NH₂NH₂*H₂O / 3.5 h / 115 °C

2: 96 percent / ethanol / 0.5 h / Heating

3: 98 percent / 4percent aq. NaOH / ethanol / 3 h / Heating

With sodium hydroxide; hydrazine hydrate; In ethanol;

DOI:10.1002/jhet.5570210539

Reference yield:

3-Methoxy-17β-hydroxyestra-1,3,5(10)-triene-17α-acetylhydrazide (95846-52-9) → 3-Methoxy-17α-<1'H-4'-(4-methoxyphenyl)-5'-thio-1',2',4'-triazoline-3'methylene>estra-1,3,5(10)-trien-17β-ol (95846-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / ethanol / 0.5 h / Heating

2: 98 percent / 4percent aq. NaOH / ethanol / 3 h / Heating

With sodium hydroxide; In ethanol;

DOI:10.1002/jhet.5570210539

upstream raw materials:

1'-(3-Methoxy-17β-hydroxyestra-1,3,5(10)-trien-17α-yl)acetyl-4'-(4-methoxyphenyl)-3'-thiosemicarbazide

<17β-Hydroxy-3-methoxy-oestra-1,3,5(10)-trien-17α-yl>-essigsaeure-aethylester

3-Methoxy-17β-hydroxyestra-1,3,5(10)-triene-17α-acetylhydrazide

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