trans-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide

Base Information

Chemical Name:trans-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide
CAS No.:1093685-40-5
Molecular Formula:C₃₁H₃₀FN₃O₂
Molecular Weight:495.597
Hs Code.:

Synonyms:trans-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide

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Chemical Property of trans-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide

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Technology Process of trans-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide

There total 13 articles about trans-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.5%

: 1093685-38-1
4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohex-3-en-1-yl]methyl}benzamide

: 1093685-40-5
trans-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide

: 1093685-39-2
cis-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; for 6h;

Reference yield:

: 1093395-66-4
4-(5-cyano-7-isopropyl-benzooxazol-2-yl)-benzoic acid

: 1093685-40-5
trans-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide

: 1093685-39-2
cis-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 20 °C

1.2: 25 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium / tetrahydrofuran; water / 0.33 h / 100 °C / Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 6 h

With 2,6-dimethylpyridine; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1093685-26-7
4-({[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}methyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

: 1093685-40-5
trans-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide

: 1093685-39-2
cis-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium / tetrahydrofuran; water / 0.33 h / 100 °C / Microwave irradiation

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 6 h

With hydrogen; potassium carbonate; palladium 10% on activated carbon; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium; In tetrahydrofuran; water;