methyl (4S,7S)-6-benzyloxycarbonyl-2-methoxy-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

Base Information

Chemical Name:methyl (4S*,7S*)-6-benzyloxycarbonyl-2-methoxy-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate
CAS No.:96657-58-8
Molecular Formula:C₁₇H₂₀N₂O₇
Molecular Weight:364.355
Hs Code.:

Synonyms:methyl (4S*,7S*)-6-benzyloxycarbonyl-2-methoxy-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

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Chemical Property of methyl (4S*,7S*)-6-benzyloxycarbonyl-2-methoxy-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

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Technology Process of methyl (4S*,7S*)-6-benzyloxycarbonyl-2-methoxy-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

There total 4 articles about methyl (4S*,7S*)-6-benzyloxycarbonyl-2-methoxy-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 96657-57-7
(3S*,6S*)-2-benzyloxycarbonyl-6-<(methoxyamino)methyl>-3-methoxycarbonylperhydro-1,2-oxazine-6-carboxylic acid

: 96657-58-8
methyl (4S*,7S*)-6-benzyloxycarbonyl-2-methoxy-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

Guidance literature:: With potassium hydrogencarbonate; methanesulfonyl chloride; tetra(n-butyl)ammonium hydrogensulfate; In chloroform; water; for 20h; Ambient temperature;
DOI:10.1016/S0040-4020(01)88799-8

Reference yield:

: 96657-56-6
methyl (3S*,6S*)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(methoxyamino)methyl>perhydro-1,2-oxazine-3-carboxylate

: 96657-58-8
methyl (4S*,7S*)-6-benzyloxycarbonyl-2-methoxy-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / trifluoroacetic acid / trifluoroacetic acid / 0.75 h / Ambient temperature

2: 53 percent / potassium bicarbonate, methanesulphonyl chloride / aq. tetra-n-butylammonium bisulphate / CHCl₃; H₂O / 20 h / Ambient temperature

With potassium hydrogencarbonate; methanesulfonyl chloride; trifluoroacetic acid; tetra(n-butyl)ammonium hydrogensulfate; In chloroform; water; trifluoroacetic acid;
DOI:10.1016/S0040-4020(01)88799-8

Reference yield:

: 96657-62-4
methyl (3S*,6S*)-6-benzhydryl-oxycarbonyl-2-benzyloxycarbonyl-6-<methyl>perhydro-1,2-oxazine-3-carboxylate

: 96657-58-8
methyl (4S*,7S*)-6-benzyloxycarbonyl-2-methoxy-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / thiourea / ethanol; ethyl acetate / 18 h / 60 °C

2: 94 percent / trifluoroacetic acid / trifluoroacetic acid / 0.75 h / Ambient temperature

3: 53 percent / potassium bicarbonate, methanesulphonyl chloride / aq. tetra-n-butylammonium bisulphate / CHCl₃; H₂O / 20 h / Ambient temperature

With potassium hydrogencarbonate; methanesulfonyl chloride; thiourea; trifluoroacetic acid; tetra(n-butyl)ammonium hydrogensulfate; In ethanol; chloroform; water; ethyl acetate; trifluoroacetic acid;
DOI:10.1016/S0040-4020(01)88799-8