1-<(4-aminophenyl)<(dimethylamino)carbonyl>methyl>cyclohexanol

Base Information

• Chemical Name: 1-<(4-aminophenyl)<(dimethylamino)carbonyl>methyl>cyclohexanol
• CAS No.: 93413-49-1
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.379
• Mol file: 93413-49-1.mol

Synonyms:1-<(4-aminophenyl)<(dimethylamino)carbonyl>methyl>cyclohexanol

Chemical Property of 1-<(4-aminophenyl)<(dimethylamino)carbonyl>methyl>cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<(4-aminophenyl)<(dimethylamino)carbonyl>methyl>cyclohexanol

There total 2 articles about 1-<(4-aminophenyl)<(dimethylamino)carbonyl>methyl>cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-bis-(chlorodimethylsilyl)ethane (13528-93-3) + 2-(4-Aminophenyl)N,N-dimethylacetamide (81709-36-6) → 1-<(4-aminophenyl)<(dimethylamino)carbonyl>methyl>cyclohexanol (93413-49-1) + 1-<(4-aminophenyl)-2-(dimethylamino)ethyl>cyclohexanol (93413-48-0)

Guidance literature:

With n-butyllithium; ammonium chloride; sodium hexamethyldisilazane; In tetrahydrofuran; hexane; cyclohexanone;

Reference yield:

2-(4-Aminophenyl)N,N-dimethylacetamide (81709-36-6) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-<(4-aminophenyl)<(dimethylamino)carbonyl>methyl>cyclohexanol (93413-49-1)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jm00172a035

Reference yield: 80.0%

1-<(4-aminophenyl)<(dimethylamino)carbonyl>methyl>cyclohexanol (93413-49-1) → 1-<(4-aminophenyl)-2-(dimethylamino)ethyl>cyclohexanol (93413-48-0)

Guidance literature:

With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; at 0 ℃; for 5h;

DOI:10.1021/jm00172a035

upstream raw materials:

2-(4-Aminophenyl)N,N-dimethylacetamide

cyclohexanone

1,2-bis-(chlorodimethylsilyl)ethane

Downstream raw materials:

1-<(4-aminophenyl)-2-(dimethylamino)ethyl>cyclohexanol

1-<2-(dimethylamino)-1-(4-nitrophenyl)ethyl>cyclohexanol