dbzC<*>dbzAp(ClPh,CNEt)

Base Information

• Chemical Name: dbzC<*>dbzAp(ClPh,CNEt)
• CAS No.: 71459-47-7
• Molecular Formula: C₄₈H₄₃Cl₂N₉O₁₄P₂
• Molecular Weight: 1102.77
• Mol file: 71459-47-7.mol

Synonyms:dbzC<*>dbzAp(ClPh,CNEt)

Chemical Property of dbzC<*>dbzAp(ClPh,CNEt)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dbzC<*>dbzAp(ClPh,CNEt)

There total 12 articles about dbzC<*>dbzAp(ClPh,CNEt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → dbzC<*>dbzAp(ClPh,CNEt) (71459-47-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine, triazole / pyridine; dioxane / 1.) 0 deg C, 1 h; 2.) room temp., 1 h

2: mesitylenesulfonyl 4-nitroimidazolide / N-methylimidazole / pyridine / 3 h / Ambient temperature

3: 2 percent benzenesulfonic acid / methanol; CHCl₃ / 0.25 h / 0 °C

With 1,2,3-triazole; mesitylenesulfonyl 4-nitro-imidazolide; triethylamine; benzenesulfonic acid; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine; methanol; chloroform;

DOI:10.1248/cpb.30.3951

Reference yield:

N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)-2'-deoxycytidylyl-(3'->5')-N-benzoyl-2'-deoxy-3'-adenylic acid, 4-chlorophenyl 2-cyanoethyl ester (71459-55-7) → dbzC<*>dbzAp(ClPh,CNEt) (71459-47-7)

Guidance literature:

With benzenesulfonic acid; In methanol; chloroform;

Reference yield:

4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N4-benzoyl-2'-deoxycytidin-3'-yl phosphate (66274-77-9) → dbzC<*>dbzAp(ClPh,CNEt) (71459-47-7)

Guidance literature:

Multi-step reaction with 2 steps

1: mesitylenesulfonyl 4-nitroimidazolide / N-methylimidazole / pyridine / 3 h / Ambient temperature

2: 2 percent benzenesulfonic acid / methanol; CHCl₃ / 0.25 h / 0 °C

With mesitylenesulfonyl 4-nitro-imidazolide; benzenesulfonic acid; 1-methyl-1H-imidazole; In pyridine; methanol; chloroform;

DOI:10.1248/cpb.30.3951

upstream raw materials:

N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)-2'-deoxycytidylyl-(3'->5')-N-benzoyl-2'-deoxy-3'-adenylic acid, 4-chlorophenyl 2-cyanoethyl ester

C₆₈H₅₉Cl₂N₉O₁₅P₂

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N⁴-benzoyl-2'-deoxycytidin-3'-yl phosphate

Downstream raw materials:

(MeO)TrdT<*>dbzA<*>dbzC<*>dbzAp(ClPh,CNEt)