(R)-1-phenylethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate

Base Information

Chemical Name:(R)-1-phenylethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate
CAS No.:1428243-72-4
Molecular Formula:C₈H₁₁N*C₁₄H₁₇NO₄
Molecular Weight:384.475
Hs Code.:

Synonyms:(R)-1-phenylethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-phenylethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate

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Technology Process of (R)-1-phenylethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate

There total 4 articles about (R)-1-phenylethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1428243-36-0,1402666-47-0,1428243-71-3
(cis)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylic acid

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1428243-37-1
(R)-1-phenylethanammonium (3R,4S)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate

: 1428243-72-4
(R)-1-phenylethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate

Guidance literature:: In acetonitrile; for 16h;

Reference yield:

: 261896-27-9
(cis)-ethyl 1-benzyl-4-methylpyrrolidine-3-carboxylate

: 1428243-37-1
(R)-1-phenylethanammonium (3R,4S)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate

: 1428243-72-4
(R)-1-phenylethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; hydrogenchloride / 15 h / Reflux

2.1: sodium hydroxide; hydrogen; hydrogenchloride; 20% palladium hydroxide on charcoal / water / 16 h / 50 °C / 1551.49 Torr / pH Ca. 2.5

3.1: sodium hydroxide / water / pH Ca_. 11

3.2: 6 h / pH Ca_. 10 - Ca_. 12

3.3: pH Ca_. 2 - Ca_. 3

4.1: acetonitrile / 16 h

With hydrogenchloride; 20% palladium hydroxide on charcoal; water; hydrogen; sodium hydroxide; In water; acetonitrile;

Reference yield:

: C₁₃H₁₇NO₂*ClH

: 1428243-37-1
(R)-1-phenylethanammonium (3R,4S)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate

: 1428243-72-4
(R)-1-phenylethanammonium (3S,4R)-1-(benzyloxycarbonyl)-4-methylpyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; hydrogen; hydrogenchloride; 20% palladium hydroxide on charcoal / water / 16 h / 50 °C / 1551.49 Torr / pH Ca. 2.5

2.1: sodium hydroxide / water / pH Ca_. 11

2.2: 6 h / pH Ca_. 10 - Ca_. 12

2.3: pH Ca_. 2 - Ca_. 3

3.1: acetonitrile / 16 h

With hydrogenchloride; 20% palladium hydroxide on charcoal; hydrogen; sodium hydroxide; In water; acetonitrile;