1,1-dimethylethyl 5-methyl-6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 5-methyl-6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate
CAS No.:1165923-91-0
Molecular Formula:C₁₆H₂₀F₃NO₅S
Molecular Weight:395.4
Hs Code.:

Synonyms:1,1-dimethylethyl 5-methyl-6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

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Chemical Property of 1,1-dimethylethyl 5-methyl-6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

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Technology Process of 1,1-dimethylethyl 5-methyl-6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

There total 18 articles about 1,1-dimethylethyl 5-methyl-6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1165923-89-6
1,1-dimethylethyl 6-hydroxy-5-methyl-3,4-dihydro-2(1H)-isoquinolinecarboxylate

: 1165923-91-0
1,1-dimethylethyl 5-methyl-6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: With pyridine; In dichloromethane; at -30 - 20 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield: 70.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: C₁₆H₂₃NO₃

: 1165923-91-0
1,1-dimethylethyl 5-methyl-6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1165923-91-0
1,1-dimethylethyl 5-methyl-6-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: toluene / 24 h / Reflux

2: hydroquinone / toluene / 24 h / Reflux

3: lithium hexamethyldisilazane / tetrahydrofuran / -63 - -60 °C

4: chloro-trimethyl-silane / tetrahydrofuran / 2 h / -70 °C

5: palladium diacetate / acetonitrile / 35 °C

6: tetrabutyl ammonium fluoride / ethyl acetate / 0.5 h

7: pyridine / dichloromethane / -30 - 20 °C / Inert atmosphere

With pyridine; chloro-trimethyl-silane; tetrabutyl ammonium fluoride; palladium diacetate; hydroquinone; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; acetonitrile;