2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isoquinoline-1,3-dione

Base Information

Chemical Name:2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isoquinoline-1,3-dione
CAS No.:676557-90-7
Molecular Formula:C₂₃H₂₂N₄O₃
Molecular Weight:402.453
Hs Code.:

2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[<i>de</i>]isoquinoline-1,3-dione

Synonyms:2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isoquinoline-1,3-dione

Suppliers and Price of 2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isoquinoline-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isoquinoline-1,3-dione

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Technology Process of 2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isoquinoline-1,3-dione

There total 3 articles about 2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isoquinoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 676557-89-4
6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isochromene-1,3-dione

: 676557-90-7
2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isoquinoline-1,3-dione

Guidance literature:: With hydrazine hydrate; In ethanol; at 40 ℃; for 2h;
DOI:10.1021/ja039395n

Reference yield:

: 81-86-7
4-bromo-1,8-naphthalenedicarboxylic anhydride

: 676557-90-7
2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isoquinoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: NEt₃ / CH₂Cl₂; N,N-dimethyl-acetamide / 0.25 h

1.2: 57 percent / Heating

2.1: 100 percent / aq. hydrazine / ethanol / 2 h / 40 °C

With hydrazine hydrate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/ja039395n

Reference yield:

: 38869-47-5,70849-64-8
4-(p-methoxyphenyl)piperazine dihydrochloride

: 676557-90-7
2-amino-6-[4-(4-methoxy-phenyl)-piperazin-1-yl]-benzo[de]isoquinoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: NEt₃ / CH₂Cl₂; N,N-dimethyl-acetamide / 0.25 h

1.2: 57 percent / Heating

2.1: 100 percent / aq. hydrazine / ethanol / 2 h / 40 °C

With hydrazine hydrate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/ja039395n