(E,3S^*,6R^*)-3,6-dimethyl-7-(triphenylmethoxy)-4-heptenoic acid, dimethylamide

Base Information

• Chemical Name: (E,3S^*,6R^*)-3,6-dimethyl-7-(triphenylmethoxy)-4-heptenoic acid, dimethylamide
• CAS No.: 113489-89-7
• Molecular Formula: C₃₀H₃₅NO₂
• Molecular Weight: 441.613
• Mol file: 113489-89-7.mol

Synonyms:(E,3S^*,6R^*)-3,6-dimethyl-7-(triphenylmethoxy)-4-heptenoic acid, dimethylamide

Chemical Property of (E,3S^*,6R^*)-3,6-dimethyl-7-(triphenylmethoxy)-4-heptenoic acid, dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E,3S^*,6R^*)-3,6-dimethyl-7-(triphenylmethoxy)-4-heptenoic acid, dimethylamide

There total 4 articles about (E,3S^*,6R^*)-3,6-dimethyl-7-(triphenylmethoxy)-4-heptenoic acid, dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,N-dimethylacetamide dimethyl acetal (18871-66-4) + (E,2R*,3S*)-2-methyl-1-(triphenylmethoxy)-4-hexen-3-ol (113489-82-0) → (E,3S*,6R*)-3,6-dimethyl-7-(triphenylmethoxy)-4-heptenoic acid, dimethylamide (113489-89-7)

Guidance literature:

In o-xylene; at 140 ℃; for 1.5h;

DOI:10.1021/jo00244a017

Reference yield:

trityl chloride (76-83-5) → (E,3S*,6R*)-3,6-dimethyl-7-(triphenylmethoxy)-4-heptenoic acid, dimethylamide (113489-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / 4-(dimethylamino)pyridine, triethylamine / CH₂Cl₂ / 2.5 h / Ambient temperature

2: 92 percent / o-xylene / 1.5 h / 140 °C

With dmap; triethylamine; In dichloromethane; o-xylene;

DOI:10.1021/jo00244a017

Reference yield:

(E)-2-methyl-4-hexene-1,3-diol (113489-76-2) → (E,3S*,6R*)-3,6-dimethyl-7-(triphenylmethoxy)-4-heptenoic acid, dimethylamide (113489-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / 4-(dimethylamino)pyridine, triethylamine / CH₂Cl₂ / 2.5 h / Ambient temperature

2: 92 percent / o-xylene / 1.5 h / 140 °C

With dmap; triethylamine; In dichloromethane; o-xylene;

DOI:10.1021/jo00244a017

upstream raw materials:

N,N-dimethylacetamide dimethyl acetal

(E,2R^*,3S^*)-2-methyl-1-(triphenylmethoxy)-4-hexen-3-ol

trityl chloride

(E)-2-methyl-4-hexene-1,3-diol