3-[2-(2-tert-butoxy-2-oxoethoxy)-5-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenyl]propanoic acid

Base Information

• Chemical Name: 3-[2-(2-tert-butoxy-2-oxoethoxy)-5-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenyl]propanoic acid
• CAS No.: 1355027-62-1
• Molecular Formula: C₃₂H₃₇N₃O₇
• Molecular Weight: 575.662
• Mol file: 1355027-62-1.mol

Synonyms:3-[2-(2-tert-butoxy-2-oxoethoxy)-5-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenyl]propanoic acid

Chemical Property of 3-[2-(2-tert-butoxy-2-oxoethoxy)-5-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenyl]propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(2-tert-butoxy-2-oxoethoxy)-5-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenyl]propanoic acid

There total 7 articles about 3-[2-(2-tert-butoxy-2-oxoethoxy)-5-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C39H43N3O7 (1355027-77-8) → 3-[2-(2-tert-butoxy-2-oxoethoxy)-5-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenyl]propanoic acid (1355027-62-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.10.078

Reference yield:

C33H33N3O5 (1355027-76-7) → 3-[2-(2-tert-butoxy-2-oxoethoxy)-5-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenyl]propanoic acid (1355027-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide

2: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide

With palladium 10% on activated carbon; hydrogen; caesium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.10.078

Reference yield:

C10H13NO3 (1016274-45-5) → 3-[2-(2-tert-butoxy-2-oxoethoxy)-5-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenyl]propanoic acid (1355027-62-1)

Guidance literature:

Multi-step reaction with 4 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

2: sulfuric acid / acetonitrile / 60 °C

3: caesium carbonate / N,N-dimethyl-formamide

4: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide

With sulfuric acid; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; caesium carbonate; triethylamine; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2011.10.078

upstream raw materials:

C₁₀H₁₃NO₃

C₂₇H₂₉N₃O₅

C₃₃H₃₃N₃O₅

C₃₉H₄₃N₃O₇

Downstream raw materials:

tert-butyl [2-(2,2-dimethyl-4,24-dioxo-3,8,11,14,17,20-hexaoxa-5,23-diazahexacosan-26-yl)-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy]acetate

[2-(21-amino-3-oxo-7,10,13,16,19-pentaoxa-4-azahenicos-1-yl)-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy]acetic acid trifluoroacetate

(2-{3-[(12-aminododecyl)amino]-3-oxopropyl}-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl] amino}phenyl)acetyl]amino}phenoxy)acetic acid trifluoroacetate

[4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-2-(3-oxo-3-{[12-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)dodecyl]amino}propyl)phenoxy]acetic acid