N-(3-amino-propyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-4-methyl-benzamide

Base Information

Chemical Name:N-(3-amino-propyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-4-methyl-benzamide
CAS No.:774536-58-2
Molecular Formula:C₂₇H₃₀ClN₅O₂
Molecular Weight:492.021
Hs Code.:

<i>N</i>-(3-amino-propyl)-<i>N</i>-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-<i>f</i>][1,2,4]triazin-2-yl)-propyl]-4-methyl-benzamide

Synonyms:N-(3-amino-propyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-4-methyl-benzamide

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Chemical Property of N-(3-amino-propyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-4-methyl-benzamide

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Technology Process of N-(3-amino-propyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-4-methyl-benzamide

There total 11 articles about N-(3-amino-propyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-4-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 628734-09-8
(+/-)-N-{3-[[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-(4-methyl-benzoyl)-amino]-propyl}-carbamic acid tert-butyl ester

: 774536-58-2
N-(3-amino-propyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-4-methyl-benzamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1016/j.bmcl.2006.05.037

Reference yield:

: 749206-48-2
1-amino-5-chloro-1H-pyrrole-2-carboxylic acid methyl ester

: 774536-58-2
N-(3-amino-propyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 10 steps

1: HCl / dioxane / 82 °C

2: Et₃N / acetonitrile / 85 °C

3: Cs₂CO₃ / dioxane / 95 °C

4: dimethylformamide / 146 °C

5: NaIO₄ / various solvent(s); tetrahydrofuran / 20 °C / pH 7

6: CH₂Cl₂ / -78 - -50 °C

7: SOCl₂; pyridine / CH₂Cl₂ / 0 - 20 °C

8: ethanol / Heating

9: Et₃N / CH₂Cl₂ / 20 °C

10: HCl / dioxane / 20 °C

With pyridine; hydrogenchloride; sodium periodate; thionyl chloride; caesium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.05.037

Reference yield:

: 628734-14-5
7-chloro-2-methyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

: 774536-58-2
N-(3-amino-propyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: Cs₂CO₃ / dioxane / 95 °C

2: dimethylformamide / 146 °C

3: NaIO₄ / various solvent(s); tetrahydrofuran / 20 °C / pH 7

4: CH₂Cl₂ / -78 - -50 °C

5: SOCl₂; pyridine / CH₂Cl₂ / 0 - 20 °C

6: ethanol / Heating

7: Et₃N / CH₂Cl₂ / 20 °C

8: HCl / dioxane / 20 °C

With pyridine; hydrogenchloride; sodium periodate; thionyl chloride; caesium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.037