Technology Process of Phenyl-vinyl-malonsaeure-diaethylester
There total 6 articles about Phenyl-vinyl-malonsaeure-diaethylester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3-oxo-butyl)-phenyl-malonic acid diethyl ester;
With
aluminum oxide; N-Methyl-picolinamidrazon;
In
1,4-dioxane;
at 90 ℃;
for 24h;
Inert atmosphere;
With
copper diacetate;
In
water; dimethyl sulfoxide;
at 20 ℃;
for 20h;
Inert atmosphere;
Glovebox;
Sealed tube;
DOI:10.1021/jacs.1c09587
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
1.2: 24 h / Inert atmosphere; Reflux
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1 h / 75 - 80 °C / Inert atmosphere
With
sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
DOI:10.1002/anie.202010839
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
at 75 - 80 ℃;
for 1h;
Inert atmosphere;
DOI:10.1002/anie.202010839
