2-methyl-acrylic acid 2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenyl ester

Base Information

• Chemical Name: 2-methyl-acrylic acid 2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenyl ester
• CAS No.: 869953-70-8
• Molecular Formula: C₂₅H₂₈O₃
• Molecular Weight: 376.496
• Mol file: 869953-70-8.mol

Synonyms:2-methyl-acrylic acid 2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenyl ester

Chemical Property of 2-methyl-acrylic acid 2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-acrylic acid 2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenyl ester

There total 3 articles about 2-methyl-acrylic acid 2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenol (869953-69-5) + Methacryloyl chloride (920-46-7,26937-45-1) → 2-methyl-acrylic acid 2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenyl ester (869953-70-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.666667h;

DOI:10.1016/j.tetlet.2005.09.023

Reference yield:

2-allyl-4-benzyloxy-1-((E)-2-methyl-but-2-enyloxy)-benzene (869953-68-4) → 2-methyl-acrylic acid 2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenyl ester (869953-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / various solvent(s) / 4 h / Heating

2: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0.67 h / 0 °C

With dmap; triethylamine; In dichloromethane; 1: Claisen rearrangement;

DOI:10.1016/j.tetlet.2005.09.023

Reference yield:

2-propenyl-4-benzyloxyphenol (194981-61-8) → 2-methyl-acrylic acid 2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenyl ester (869953-70-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

2: 85 percent / various solvent(s) / 4 h / Heating

3: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0.67 h / 0 °C

With dmap; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1: Mitsunobu reaction / 2: Claisen rearrangement;

DOI:10.1016/j.tetlet.2005.09.023

upstream raw materials:

2-allyl-4-benzyloxy-6-(1,2-dimethyl-allyl)-phenol

Methacryloyl chloride

2-allyl-4-benzyloxy-1-((E)-2-methyl-but-2-enyloxy)-benzene

2-propenyl-4-benzyloxyphenol

Downstream raw materials:

7-benzyloxy-9-(1,2-dimethyl-allyl)-3-methyl-5H-1-benzoxepin-2-one