8-ETHYNYLQUINOLINE

Base Information

• Chemical Name: 8-ETHYNYLQUINOLINE
• CAS No.: 103987-81-1
• Molecular Formula: C11H7 N
• Molecular Weight: 153.183
• Mol file: 103987-81-1.mol

Synonyms:8-Ethynylquinoline

Chemical Property of 8-ETHYNYLQUINOLINE

Chemical Property:

• Boiling Point: 282.4±13.0 °C(Predicted)
• PKA: 3.34±0.17(Predicted)
• PSA: 12.89000
• Density: 1.13±0.1 g/cm3(Predicted)
• LogP: 2.21610
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

8-Ethynylquinoline 90+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-ETHYNYLQUINOLINE

There total 4 articles about 8-ETHYNYLQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

8-((trimethylsilyl)ethynyl)quinoline (895164-50-8) → 8-ethynylquinoline (103987-81-1)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 0.25h;

DOI:10.1039/b603983a

Reference yield: 80.0%

dimethylhydroxymethyl-8-quinolylacetylene (869208-50-4) → 8-ethynylquinoline (103987-81-1)

Guidance literature:

With sodium hydroxide; In toluene; at 120 ℃; for 0.5h;

Reference yield:

8-quinolinol (148-24-3,24804-14-6) → 8-ethynylquinoline (103987-81-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / copper iodide; tetrakis(triphenylphosphine)Pd; piperidine / 2 h / 90 °C

2: 99 percent / sodium hydroxide / methanol; H₂O / 0.25 h / 20 °C

With piperidine; sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water;

DOI:10.1039/b603983a

upstream raw materials:

8-((trimethylsilyl)ethynyl)quinoline

dimethylhydroxymethyl-8-quinolylacetylene

8-quinolinol

Downstream raw materials:

8-(phenylethynyl)quinoline