(1S)-1-[4-[5-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-3-yl]phenyl]ethanamine trifluoroacetate

Base Information

Chemical Name:(1S)-1-[4-[5-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-3-yl]phenyl]ethanamine trifluoroacetate
CAS No.:1569310-77-5
Molecular Formula:C₂HF₃O₂*C₁₉H₁₆Cl₃F₃N₂
Molecular Weight:549.728
Hs Code.:

Synonyms:(1S)-1-[4-[5-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-3-yl]phenyl]ethanamine trifluoroacetate

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Chemical Property of (1S)-1-[4-[5-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-3-yl]phenyl]ethanamine trifluoroacetate

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Technology Process of (1S)-1-[4-[5-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-3-yl]phenyl]ethanamine trifluoroacetate

There total 6 articles about (1S)-1-[4-[5-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-3-yl]phenyl]ethanamine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1556019-46-5
tert-butyl N-[(1S)-1-[4-[5-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-3-yl]phenyl]ethyl]carbamate

: 76-05-1
trifluoroacetic acid

: 1569310-77-5
(1S)-1-[4-[5-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-3-yl]phenyl]ethanamine trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 1556019-44-3
tert-butyl N-[(1S)-1-[4-(trimethylsilylmethylcarbamothioyl)phenyl]ethyl]carbamate

: 1569310-77-5
(1S)-1-[4-[5-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-3-yl]phenyl]ethanamine trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h

1.2: 3 h / 0 - 20 °C

2.1: dichloromethane / 5 h / 20 °C

With potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 27298-97-1
(S)-1-(4-bromophenyl)ethylamine

: 1569310-77-5
(1S)-1-[4-[5-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-3-yl]phenyl]ethanamine trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 0.42 h

2.1: methyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 0.5 h

2.3: 1 h / -70 - 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

4.1: Lawessons reagent / tetrahydrofuran / 4 h / 65 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 4 h

5.2: 3 h / 0 - 20 °C

6.1: dichloromethane / 5 h / 20 °C

With Lawessons reagent; methyllithium; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;