(Z)-5-(3,4-dihydroxybenzylidene)-3-((4'-(trifluoromethoxy)-[1,1-biphenyl]-3-yl)methyl)thiazolidine-2,4-dione

Base Information

Chemical Name:(Z)-5-(3,4-dihydroxybenzylidene)-3-((4'-(trifluoromethoxy)-[1,1-biphenyl]-3-yl)methyl)thiazolidine-2,4-dione
CAS No.:1609175-80-5
Molecular Formula:C₂₄H₁₆F₃NO₅S
Molecular Weight:487.456
Hs Code.:

Synonyms:(Z)-5-(3,4-dihydroxybenzylidene)-3-((4'-(trifluoromethoxy)-[1,1-biphenyl]-3-yl)methyl)thiazolidine-2,4-dione

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Chemical Property of (Z)-5-(3,4-dihydroxybenzylidene)-3-((4'-(trifluoromethoxy)-[1,1-biphenyl]-3-yl)methyl)thiazolidine-2,4-dione

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Technology Process of (Z)-5-(3,4-dihydroxybenzylidene)-3-((4'-(trifluoromethoxy)-[1,1-biphenyl]-3-yl)methyl)thiazolidine-2,4-dione

There total 3 articles about (Z)-5-(3,4-dihydroxybenzylidene)-3-((4'-(trifluoromethoxy)-[1,1-biphenyl]-3-yl)methyl)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (Z)-3-(3-bromobenzyl)-5-(3,4-dihydroxybenzylidene)thiazolidine-2,4-dione

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1609175-80-5
(Z)-5-(3,4-dihydroxybenzylidene)-3-((4'-(trifluoromethoxy)-[1,1-biphenyl]-3-yl)methyl)thiazolidine-2,4-dione

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; for 3h; Reflux;

Reference yield:

: 823-78-9
meta-bromobenzyl bromide

: 1609175-80-5
(Z)-5-(3,4-dihydroxybenzylidene)-3-((4'-(trifluoromethoxy)-[1,1-biphenyl]-3-yl)methyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 26 h / Reflux

2: acetic acid; piperidine / toluene / 0.67 h / Reflux

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 3 h / Reflux

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 848606-46-2
3-(3-bromobenzyl)thiazolidine-2,4-dione

: 1609175-80-5
(Z)-5-(3,4-dihydroxybenzylidene)-3-((4'-(trifluoromethoxy)-[1,1-biphenyl]-3-yl)methyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; piperidine / toluene / 0.67 h / Reflux

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 3 h / Reflux

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetic acid; In tetrahydrofuran; toluene;