1-<2-oxo-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrobromide

Base Information

• Chemical Name: 1-<2-oxo-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrobromide
• CAS No.: 74178-83-9
• Molecular Formula: BrH*C₂₀H₂₁N₃O₄
• Molecular Weight: 448.316

Synonyms:1-<2-oxo-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrobromide

Chemical Property of 1-<2-oxo-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrobromide

Chemical Property:

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Technology Process of 1-<2-oxo-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrobromide

There total 3 articles about 1-<2-oxo-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.7%

1-<2-oxo-2-(3,4-methylenedioxyoxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine (74178-79-3) → 1-<2-oxo-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrobromide (74178-83-9)

Guidance literature:

With hydrogenchloride; boron tribromide; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1248/cpb.30.462

Reference yield:

1-(benzo[1,3]dioxol-5-yl)-2-bromoethanone (40288-65-1) → 1-<2-oxo-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrobromide (74178-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 63.2 percent / Et₃N / methanol / 6 h / Ambient temperature

2: 80.7 percent / HCl,BBr₃ / CH₂Cl₂ / 12 h / Ambient temperature

With hydrogenchloride; boron tribromide; triethylamine; In methanol; dichloromethane;

DOI:10.1248/cpb.30.462

Reference yield:

4-(2-keto-1-benzimidazolinyl)piperidine (20662-53-7) → 1-<2-oxo-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrobromide (74178-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 63.2 percent / Et₃N / methanol / 6 h / Ambient temperature

2: 80.7 percent / HCl,BBr₃ / CH₂Cl₂ / 12 h / Ambient temperature

With hydrogenchloride; boron tribromide; triethylamine; In methanol; dichloromethane;

DOI:10.1248/cpb.30.462

upstream raw materials:

1-<2-oxo-2-(3,4-methylenedioxyoxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine

1-(benzo[1,3]dioxol-5-yl)-2-bromoethanone

4-(2-keto-1-benzimidazolinyl)piperidine

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