6-Fluoro-3-hydroxy-3-(2-oxo-cyclohexyl)-1,3-dihydro-indol-2-one

Base Information

• Chemical Name: 6-Fluoro-3-hydroxy-3-(2-oxo-cyclohexyl)-1,3-dihydro-indol-2-one
• CAS No.: 124929-30-2
• Molecular Formula: C₁₄H₁₄FNO₃
• Molecular Weight: 263.268
• Mol file: 124929-30-2.mol

Synonyms:6-Fluoro-3-hydroxy-3-(2-oxo-cyclohexyl)-1,3-dihydro-indol-2-one

Chemical Property of 6-Fluoro-3-hydroxy-3-(2-oxo-cyclohexyl)-1,3-dihydro-indol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Fluoro-3-hydroxy-3-(2-oxo-cyclohexyl)-1,3-dihydro-indol-2-one

There total 1 articles about 6-Fluoro-3-hydroxy-3-(2-oxo-cyclohexyl)-1,3-dihydro-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-fluoroisatin (324-03-8) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 6-Fluoro-3-hydroxy-3-(2-oxo-cyclohexyl)-1,3-dihydro-indol-2-one (124929-30-2)

Guidance literature:

With diethylamine; In ethanol; for 1h; Heating;

Reference yield: 60.0%

6-Fluoro-3-hydroxy-3-(2-oxo-cyclohexyl)-1,3-dihydro-indol-2-one (124929-30-2) → 6-Fluoro-3-[2-oxo-cyclohex-(E)-ylidene]-1,3-dihydro-indol-2-one

Guidance literature:

With hydrogenchloride; In acetic acid; for 0.25h;

DOI:10.1016/S0022-1139(00)84371-7

Reference yield:

6-Fluoro-3-hydroxy-3-(2-oxo-cyclohexyl)-1,3-dihydro-indol-2-one (124929-30-2) → C21H17F2N3OS

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / conc. HCl / acetic acid / 0.25 h

2: 55 percent / KOH / ethanol / 12 h / Heating

With hydrogenchloride; potassium hydroxide; In ethanol; acetic acid;

DOI:10.1016/S0022-1139(00)84371-7

upstream raw materials:

6-fluoroisatin

cyclohexanone