(E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid

Base Information

• Chemical Name: (E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid
• CAS No.: 1354964-59-2
• Molecular Formula: C₁₇H₁₀Cl₂N₄O₄S
• Molecular Weight: 437.263
• Mol file: 1354964-59-2.mol

Synonyms:(E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid

Chemical Property of (E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid

There total 4 articles about (E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

4-(3,4-dichloro-phenyl)-thiazol-2-yl-hydrazine (312303-66-5) + (2-nitro-phenyl)-glyoxylic acid (610-33-3) → (E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid (1354964-59-2) + (Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid (1354964-58-1)

Guidance literature:

With acetic acid; In ethanol; at 90 ℃; for 1h;

Reference yield:

o-nitromandelic acid (67603-23-0) → (E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid (1354964-59-2) + (Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid (1354964-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate; sodium hydroxide / water / 2 h / 0 °C

2: acetic acid / ethanol / 1 h / 90 °C

With potassium permanganate; acetic acid; sodium hydroxide; In ethanol; water;

Reference yield:

2-nitro-benzaldehyde (552-89-6) → (E)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid (1354964-59-2) + (Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-2-(2-nitrophenyl)acetic acid (1354964-58-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogensulfite / water / 0.17 h

1.2: 5 h / 20 °C / Cooling with ice

2.1: hydrogenchloride; water / 3 h / Reflux

3.1: potassium permanganate; sodium hydroxide / water / 2 h / 0 °C

4.1: acetic acid / ethanol / 1 h / 90 °C

With hydrogenchloride; potassium permanganate; water; sodium hydrogensulfite; acetic acid; sodium hydroxide; In ethanol; water;

upstream raw materials:

2-nitro-benzaldehyde

2-hydroxy-2-[2-nitrophenyl]acetonitrile

o-nitromandelic acid

4-(3,4-dichloro-phenyl)-thiazol-2-yl-hydrazine