Technology Process of 2-(2-cyclopent-1-enyl-3-methyl-benzoylamino)-5-fluoro-indan-2-carboxylic acid ethyl ester
There total 7 articles about 2-(2-cyclopent-1-enyl-3-methyl-benzoylamino)-5-fluoro-indan-2-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
palladium anchored homogeneous catalyst, FibreCatPd(0) (4.84percentPd);
In
1,4-dioxane; ethanol; water;
at 110 ℃;
for 8h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium permanganate; water / tert-butyl alcohol / Heating / reflux
1.2: pH 1
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Heating / reflux
2.2: 0 °C
3.1: phosphorus tribromide / dichloromethane / 0.75 h / 0 °C
4.1: tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / 18 h / Heating / reflux
5.1: hydrogenchloride; water / methanol / 2 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C
7.1: potassium carbonate / palladium anchored homogeneous catalyst, FibreCatPd(0) (4.84percentPd) / 1,4-dioxane; ethanol; water / 8 h / 110 °C / Microwave irradiation
With
hydrogenchloride; potassium permanganate; lithium aluminium tetrahydride; water; tetra(n-butyl)ammonium hydrogensulfate; phosphorus tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
palladium anchored homogeneous catalyst, FibreCatPd(0) (4.84percentPd);
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Heating / reflux
1.2: 0 °C
2.1: phosphorus tribromide / dichloromethane / 0.75 h / 0 °C
3.1: tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / 18 h / Heating / reflux
4.1: hydrogenchloride; water / methanol / 2 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C
6.1: potassium carbonate / palladium anchored homogeneous catalyst, FibreCatPd(0) (4.84percentPd) / 1,4-dioxane; ethanol; water / 8 h / 110 °C / Microwave irradiation
With
hydrogenchloride; lithium aluminium tetrahydride; water; tetra(n-butyl)ammonium hydrogensulfate; phosphorus tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
palladium anchored homogeneous catalyst, FibreCatPd(0) (4.84percentPd);
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
