[(3R,4S)-1-(5-{1-[5-(1,1-difluoroethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-ylmethoxy}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[(3R,4S)-1-(5-{1-[5-(1,1-difluoroethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-ylmethoxy}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester
CAS No.:1351342-63-6
Molecular Formula:C₂₉H₃₅F₄N₇O₄
Molecular Weight:621.635
Hs Code.:

[(3R,4S)-1-(5-{1-[5-(1,1-difluoroethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-ylmethoxy}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Synonyms:[(3R,4S)-1-(5-{1-[5-(1,1-difluoroethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-ylmethoxy}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

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Chemical Property of [(3R,4S)-1-(5-{1-[5-(1,1-difluoroethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-ylmethoxy}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

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Technology Process of [(3R,4S)-1-(5-{1-[5-(1,1-difluoroethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-ylmethoxy}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

There total 6 articles about [(3R,4S)-1-(5-{1-[5-(1,1-difluoroethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-ylmethoxy}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 373-96-6
2,2-difluoropropanoic acid

: 1351342-62-5
((3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(N-hydroxycarbamimidoyl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester

: 1351342-63-6
[(3R,4S)-1-(5-{1-[5-(1,1-difluoroethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-ylmethoxy}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield:

: 1245079-22-4
[(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351342-63-6
[(3R,4S)-1-(5-{1-[5-(1,1-difluoroethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-ylmethoxy}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 36 h / 100 °C

2: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h

3: sodium hydrogencarbonate / dichloromethane; water / 17.25 h / 0 - 20 °C

4: hydroxylamine / ethanol; water / 16.17 h / 40 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 20 °C

With hydrogen; hydroxylamine; sodium hydrogencarbonate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1351342-50-1
4-(2-chloropyrimidin-5-yloxymethyl)piperidine-1-carboxylic acid benzyl ester

: 1351342-63-6
[(3R,4S)-1-(5-{1-[5-(1,1-difluoroethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-ylmethoxy}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 36 h / 100 °C

2: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h

3: sodium hydrogencarbonate / dichloromethane; water / 17.25 h / 0 - 20 °C

4: hydroxylamine / ethanol; water / 16.17 h / 40 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 20 °C

With hydrogen; hydroxylamine; sodium hydrogencarbonate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;