7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl dihydrogen phosphate

Base Information

Chemical Name:7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl dihydrogen phosphate
CAS No.:1361005-57-3
Molecular Formula:C₂₄H₁₈ClF₃NO₅P
Molecular Weight:523.833
Hs Code.:

Synonyms:7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl dihydrogen phosphate

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Chemical Property of 7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl dihydrogen phosphate

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Technology Process of 7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl dihydrogen phosphate

There total 9 articles about 7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1361005-55-1
dibenzyl (7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl)phosphate

: 1361005-57-3
7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl dihydrogen phosphate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/jm201179h

Reference yield:

: 1361004-87-6
7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4(1H)-one

: 1361005-57-3
7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 0.17 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; methanol; mineral oil;
DOI:10.1021/jm201179h

Reference yield:

: 1361005-66-4
1-(4-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol

: 1361005-57-3
7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4-yl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / butan-1-ol / 24 h / 130 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

3.2: 0.33 h / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol / 0.17 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; mineral oil; butan-1-ol;
DOI:10.1021/jm201179h