C₂₁H₁₈Cl₂N₄O₃S

Base Information

• Chemical Name: C₂₁H₁₈Cl₂N₄O₃S
• CAS No.: 1416698-74-2
• Molecular Formula: C₂₁H₁₈Cl₂N₄O₃S
• Molecular Weight: 477.371
• Mol file: 1416698-74-2.mol

Synonyms:C₂₁H₁₈Cl₂N₄O₃S

Chemical Property of C₂₁H₁₈Cl₂N₄O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₈Cl₂N₄O₃S

There total 10 articles about C₂₁H₁₈Cl₂N₄O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C29H24Cl2N4O5S → C21H18Cl2N4O3S (1416698-74-2)

Guidance literature:

With sulfuric acid; at 0 - 5 ℃;

DOI:10.1016/j.ejmech.2012.10.005

Reference yield:

methyl 4-((methylsulfinyl)methyl)benzoate (199534-98-0) → C21H18Cl2N4O3S (1416698-74-2)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium azide; sulfuric acid / chloroform / 15 h / -20 - 50 °C / Inert atmosphere

2: pyridine / dichloromethane; toluene / 3 h / 15 - 30 °C / Inert atmosphere

3: water; sodium hydroxide / tetrahydrofuran / 3 h / 25 - 30 °C

4: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 10 - 30 °C / Inert atmosphere

5: tetrahydrofuran / 2 h / 10 - 30 °C / Inert atmosphere

6: sulfuric acid / 0 - 5 °C

With pyridine; sodium azide; oxalyl dichloride; sulfuric acid; water; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; chloroform; toluene;

DOI:10.1016/j.ejmech.2012.10.005

Reference yield:

methyl 4-[(methylsulfanyl)methyl]benzoate (67003-49-0) → C21H18Cl2N4O3S (1416698-74-2)

Guidance literature:

Multi-step reaction with 7 steps

1: dihydrogen peroxide; vanadium(V) oxide / acetonitrile / 5 h / -20 - 30 °C / Inert atmosphere

2: sodium azide; sulfuric acid / chloroform / 15 h / -20 - 50 °C / Inert atmosphere

3: pyridine / dichloromethane; toluene / 3 h / 15 - 30 °C / Inert atmosphere

4: water; sodium hydroxide / tetrahydrofuran / 3 h / 25 - 30 °C

5: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 10 - 30 °C / Inert atmosphere

6: tetrahydrofuran / 2 h / 10 - 30 °C / Inert atmosphere

7: sulfuric acid / 0 - 5 °C

With pyridine; sodium azide; vanadium(V) oxide; oxalyl dichloride; sulfuric acid; water; dihydrogen peroxide; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; chloroform; toluene; acetonitrile;

DOI:10.1016/j.ejmech.2012.10.005

upstream raw materials:

methyl 4-((methylsulfinyl)methyl)benzoate

methyl 4-[(methylsulfanyl)methyl]benzoate

5-chloro-2-nitrobenzoic acid

2-amino-5-chloro-N-(5-chloro-pyridin-2-yl)-benzamide