2-Pyridinesulfonamide,N-phenyl-(9CI)

Base Information

• Chemical Name: 2-Pyridinesulfonamide,N-phenyl-(9CI)
• CAS No.: 103863-00-9
• Molecular Formula: C11H10 N2 O2 S
• Molecular Weight: 234.279
• Mol file: 103863-00-9.mol

Synonyms:2-Pyridinesulfonanilide(6CI); N-(2-Pyridylsulfonyl)aniline

Chemical Property of 2-Pyridinesulfonamide,N-phenyl-(9CI)

Chemical Property:

• PSA: 67.44000
• LogP: 3.03620

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinesulfonamide,N-phenyl-(9CI)

There total 7 articles about 2-Pyridinesulfonamide,N-phenyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

pyridine-2-sulfonyl fluoride (878376-35-3) + aniline (62-53-3) → N-Phenylpyridine-2-sulfonamide (103863-00-9)

Guidance literature:

With calcium(II) bis(trifluoromethanesulfonyl)imide; In tert-Amyl alcohol; at 60 ℃; for 24h;

DOI:10.1021/acs.orglett.8b01520

Reference yield: 92.0%

pyridine-2-sulfonyl chloride (66715-65-9) + aniline (62-53-3) → N-Phenylpyridine-2-sulfonamide (103863-00-9)

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201105611

Reference yield: 78.0%

2,4,6-trichlorophenyl pyridine-2-sulfonate + aniline (62-53-3) → N-Phenylpyridine-2-sulfonamide (103863-00-9)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01540

upstream raw materials:

pyridine-2-sulfonyl chloride

aniline

2-Sulfanylpyridine

2-bromo-pyridine

Downstream raw materials:

N,N-diphenylpyridine-2-sulfonamide

aniline

2-N,N-diphenylaminopyridine

C₁₅H₁₇N₃O₃S

Refernces

• 1、 Holden, Catherine M.,Sohel, Shariar M. A.,Greaney, Michael F.. "Metal Free Bi(hetero)aryl Synthesis: A Benzyne Truce-Smiles Rearrangement". supporting information. p. 2450 - 2453. Retrieved 2016/02/18.
• 2、 Martinez, Angel Manu,Rodriguez, Nuria,Arrayas, Ramon Gomez,Carretero, Juan C.. "Copper-catalyzed ortho-C-H amination of protected anilines with secondary amines". supporting information. p. 2801 - 2803. Retrieved 2014/03/21.