t-butyl (2S)-t-butoxy-4-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]butyrate

Base Information

Chemical Name:t-butyl (2S)-t-butoxy-4-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]butyrate
CAS No.:324781-29-5
Molecular Formula:C₂₈H₄₁N₅O₄
Molecular Weight:511.665
Hs Code.:

Synonyms:t-butyl (2S)-t-butoxy-4-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]butyrate

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Chemical Property of t-butyl (2S)-t-butoxy-4-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]butyrate

Chemical Property:

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Technology Process of t-butyl (2S)-t-butoxy-4-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]butyrate

There total 8 articles about t-butyl (2S)-t-butoxy-4-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 247034-90-8
4-{4-(Pyrimidin-2-ylamino)piperidin-1-yl}benzoic acid

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: 324781-29-5
t-butyl (2S)-t-butoxy-4-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]butyrate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N-methyl-acetamide; dichloromethane;

Reference yield:

: 247034-90-8
4-{4-(Pyrimidin-2-ylamino)piperidin-1-yl}benzoic acid

: tert-butyl 4-amino-(2S)-tert-butoxybutyrate

: 324781-29-5
t-butyl (2S)-t-butoxy-4-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]butyrate

Guidance literature:: 4-{4-(Pyrimidin-2-ylamino)piperidin-1-yl}benzoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h;

tert-butyl 4-amino-(2S)-tert-butoxybutyrate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at -10 ℃; for 2h;
DOI:10.1016/j.bmc.2005.10.061

Reference yield:

: 247034-88-4
ethyl 4-(4-aminopiperidin-1-yl)benzoate

: 324781-29-5
t-butyl (2S)-t-butoxy-4-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]butyrate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 64 percent / (i-Pr)2NEt / dimethylformamide / 10 h / 125 °C

2.1: 82 percent / NaOH / methanol; tetrahydrofuran; H₂O / 8 h / 40 °C

3.1: (i-Pr)2NEt; BOP / dimethylformamide; CH₂Cl₂ / 3 h / 20 °C

3.2: (i-Pr)2NEt / dimethylformamide; CH₂Cl₂ / 2 h / -10 °C

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.061