(2R,3S,4S,5S)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

Base Information

Chemical Name:(2R,3S,4S,5S)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide
CAS No.:1360822-25-8
Molecular Formula:C₃₀H₃₂Cl₂FN₃O₅S
Molecular Weight:636.572
Hs Code.:

(2R,3S,4S,5S)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

Synonyms:(2R,3S,4S,5S)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

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Chemical Property of (2R,3S,4S,5S)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

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Technology Process of (2R,3S,4S,5S)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

There total 9 articles about (2R,3S,4S,5S)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: rac-(2S,3R,4R,5R)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

: 1360821-65-3
rac-(2S,3R,4R,5R)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

: 1360822-25-8
(2R,3S,4S,5S)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

Guidance literature:: With chiral SFC chromatography column; Resolution of racemate;

Reference yield:

: 2987-16-8
3,3-dimethylbutyrylaldehyde

: 1360821-65-3
rac-(2S,3R,4R,5R)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

: 1360822-25-8
(2R,3S,4S,5S)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 4 h / 20 °C

2.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

2.2: 66 h / 40 °C

3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride / dichloromethane / 0.13 h / 20 °C

4.2: 3 h / 20 °C

4.3: 1 h / 20 °C

5.1: chiral SFC chromatography column / Resolution of racemate

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; Diphenylphosphinic chloride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1360822-17-8
ethyl 2-(5-chloro-3-nitrothiophen-2-yl)acetate

: 1360821-65-3
rac-(2S,3R,4R,5R)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

: 1360822-25-8
(2R,3S,4S,5S)-2'-chloro-4-(3-chloro-2-fluorophenyl)-N-(4-(2-hydroxyethoxy)-2-methoxyphenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium chloride; zinc / methanol / 2 h / 20 °C

2.1: trimethylaluminum / toluene / 0 - 10 °C

3.1: hydrogenchloride / water; acetic acid / 24 h / 20 °C

4.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

4.2: 66 h / 40 °C

5.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride / dichloromethane / 0.13 h / 20 °C

6.2: 3 h / 20 °C

6.3: 1 h / 20 °C

7.1: chiral SFC chromatography column / Resolution of racemate

With hydrogenchloride; trimethylaluminum; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; zinc; Diphenylphosphinic chloride; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; toluene;