Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-amide

Base Information

• Chemical Name: Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-amide
• CAS No.: 80972-17-4
• Molecular Formula: C₂₅H₂₅N₃O₃S
• Molecular Weight: 447.558
• Mol file: 80972-17-4.mol

Synonyms:Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-amide

Chemical Property of Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-amide

There total 4 articles about Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

piperidine (110-89-4) + 3-(3-Cyano-phenyl)-3-(naphthalene-2-sulfonylamino)-propionyl chloride (80972-04-9) → Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-amide (80972-17-4)

Guidance literature:

In benzene; Ambient temperature;

Reference yield:

3-Cyanobenzaldehyde (24964-64-5) → Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-amide (80972-17-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 33 percent / CH₃COONH₄ / aq. ethanol / 4 h / Heating

2: 65 percent / KOH (1mol/l) / diethyl ether / 12 h / Ambient temperature

3: SOCl₂ / 1 h / Heating

4: 53 percent / benzene / Ambient temperature

With potassium hydroxide; thionyl chloride; ammonium acetate; In diethyl ether; ethanol; benzene;

Reference yield:

β-(m-Cyanphenyl)-β-alanin (80971-96-6,761396-82-1,791778-00-2) → Naphthalene-2-sulfonic acid [1-(3-cyano-phenyl)-3-oxo-3-piperidin-1-yl-propyl]-amide (80972-17-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / KOH (1mol/l) / diethyl ether / 12 h / Ambient temperature

2: SOCl₂ / 1 h / Heating

3: 53 percent / benzene / Ambient temperature

With potassium hydroxide; thionyl chloride; In diethyl ether; benzene;

upstream raw materials:

piperidine

3-(3-Cyano-phenyl)-3-(naphthalene-2-sulfonylamino)-propionyl chloride

3-Cyanobenzaldehyde

β-(m-Cyanphenyl)-β-alanin

Downstream raw materials:

3-[1-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperidin-1-yl-propyl]-benzamidine; hydriodide

3-[1-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperidin-1-yl-propyl]-thiobenzamide